Single Nucleotide Polymorphism in DNMT3B Promoter and the Risk for Idiopathic Thrombocytopenic Purpura in Chinese Population

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• 作者：Zhenping Chen ; Zeping Zhou ; Xiaoli Chen ; Jianhui Xu ; Aijuan Liu ; Weiting Du ; Dongsheng Gu ; Jing Ge ; Zhenxing Guo and Xiaoyan Wang ; et al.
• 关键词：DNA Methyltransferase 3B ; idiopathic thrombocytopenic purpura ; polymorphism
• 刊名：Journal of Clinical Immunology
• 出版年：2008
• 出版时间：September, 2008
• 年：2008
• 卷：28
• 期：5
• 页码：399-404
• 全文大小：151.0 KB

文摘

Objective Epigenetic changes in gene expression, including DNA methylation and histone modifications, might contribute to autoimmunity. DNA methylation is mediated by a family of DNA methyltransferases. Polymorphisms of the DNA methyltransferase 3B (DNMT3B) gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to some diseases. The purpose of this study was to investigate the association between the single nucleotide polymorphism (SNP) in promoter of the DNMT3B gene and the risk for development of idiopathic thrombocytopenic purpura (ITP).