MicroRNA profiling of rhesus macaque embryonic stem cells

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• 作者：Zhenghua Sun (1) (3) (4)
  Qiang Wei (2) (3) (4)
  Yanfeng Zhang (1) (3) (4)
  Xiechao He (2) (3)
  Weizhi Ji (2) (3)
  Bing Su (1) (3)
  
• 刊名：BMC Genomics
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：4166KB
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• 作者单位：Zhenghua Sun (1) (3) (4)
  Qiang Wei (2) (3) (4)
  Yanfeng Zhang (1) (3) (4)
  Xiechao He (2) (3)
  Weizhi Ji (2) (3)
  Bing Su (1) (3)
  
  1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
  3. Kunming Biomed International and National Engineering Research Center of Biomedicine and Animal Science, Kunming, 650051, China
  4. Graduate School of Chinese Academy of Sciences, Beijing, 100049, China
  2. Department of Reproduction and Development, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
  

文摘

Background MicroRNAs (miRNAs) play important roles in embryonic stem cell (ESC) self-renewal and pluripotency. Numerous studies have revealed human and mouse ESC miRNA profiles. As a model for human-related study, the rhesus macaque is ideal for delineating the regulatory mechanisms of miRNAs in ESCs. However, studies on rhesus macaque (r)ESCs are lacking due to limited rESC availability and a need for systematic analyses of fundamental rESC characteristics. Results We established three rESC lines and profiled microRNA using Solexa sequencing resulting in 304 known and 66 novel miRNAs. MiRNA profiles were highly conserved between rESC lines and predicted target genes were significantly enriched in differentiation pathways. Further analysis of the miRNA-target network indicated that gene expression regulated by miRNAs was negatively correlated to their evolutionary rate in rESCs. Moreover, a cross-species comparison revealed an overall conservation of miRNA expression patterns between human, mouse and rhesus macaque ESCs. However, we identified three miRNA clusters (miR-467, the miRNA cluster in the imprinted Dlk1-Dio3 region and C19MC) that showed clear interspecies differences. Conclusions rESCs share a unique miRNA set that may play critical roles in self-renewal and pluripotency. MiRNA expression patterns are generally conserved between species. However, species and/or lineage specific miRNA regulation changed during evolution.