Atorvastatin in improvement of cognitive impairments caused by amyloid β in mice: involvement of inflammatory reaction

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• 作者：Liandong Zhao ; Tingting Chen ; Chonghui Wang ; Guoxi Li ; Wenhui Zhi ; Jun Yin…
• 关键词：Alzheimer’s disease ; Atorvastatin ; Amyloid ; β ; Inflammatory ; Long ; term potentiation
• 刊名：BMC Neurology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：1,153 KB
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• 作者单位：Liandong Zhao (1) (2)
  Tingting Chen (3)
  Chonghui Wang (3)
  Guoxi Li (3)
  Wenhui Zhi (3)
  Jun Yin (3)
  Qi Wan (1)
  Ling Chen (3) (4)
  
  1. Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China
  2. Department of Neurology, The Second Hospital of Huaian, Huaian, Jiangsu, 223002, China
  3. Department of Physiology, Nanjing Medical University, Nanjing, 210029, China
  4. Laboratory of Reproductive Medicine, Department of Physiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, China
  
• 刊物主题：Neurology; Neurochemistry; Neurosurgery;
• 出版者：BioMed Central
• ISSN：1471-2377

文摘

Background The production of inflammatory cytokines resulting from amyloid β (Aβ) is associated with the initiation of Alzheimer’s disease (AD). Atorvastatin (ATV) has been reported to improve AD, however, it is unclear how the anti-inflammatory mechanism is linked with its protection against the impairment of spatial cognitive function in AD. The present study was designed to explore what mechanism was possibly involved in the anti-inflammatory pathway in regard to the ATV treatment of AD.