Evaluation of Immunosuppressive Activity of Demethylzeylasteral in a Beagle Dog Kidney Transplantation Model

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• 作者：Huimin An ; Yu Zhu ; Wenping Xu ; Yujun Liu…
• 关键词：Kidney transplantation model ; The immunosuppressive activity of demethylzeylasteral (T ; 96) ; Immunosuppressive monomer ; Cyclosporine A (CsA) ; Inhibitory effect ; Immune rejection
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：73
• 期：3
• 页码：673-679
• 全文大小：9,924 KB
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• 作者单位：Huimin An (1)
  Yu Zhu (1)
  Wenping Xu (1)
  Yujun Liu (1)
  Jianping Zhang (1)
  Zongming Lin (1)
  
  1. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

Several monomers isolated from Tripterygium wilfordii Hook f. (Celastraceae) have attracted worldwide interest. In this study, we established a simple and reliable kidney transplantation model in beagle dog to evaluate the immunosuppressive activity of demethylzeylasteral (T-96), an immunosuppressive monomer isolated from the root xylem of T. wilfordii. Recipient and donor male beagle dogs were obtained from two different breeders to ensure MHC mismatching. All dogs were randomly divided into six groups following kidney transplantation, and different doses of T-96 or cyclosporine A (CsA) were administered to each group during 14 days of observation. The results showed that T-96 alone at a dosage of 10 or 20 mg/kg/day prolonged graft survival up to 10.83 ± 1.47 or 11.17 ± 1.47 days. A combination of T-96 and CsA significantly prolonged the survival time to 13.33 ± 1.75 days. The results demonstrated that T-96 can inhibit acute rejection in kidney transplantation, and the inhibitory effect of T-96 was enhanced when combined with CsA, which suggests the possible use in organ transplantation to prevent immune rejection. Keywords Kidney transplantation model The immunosuppressive activity of demethylzeylasteral (T-96) Immunosuppressive monomer Cyclosporine A (CsA) Inhibitory effect Immune rejection