NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure

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• 作者：Wenyan Li ; Yumei Chang ; Shuang Liang ; Zhenyu Zhong ; Xiujin Li…
• 关键词：Listeria monocytogenes ; Listeriolysin O ; Pregnancy failure ; Inflammasome ; NLRP3
• 刊名：BMC Veterinary Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：1
• 全文大小：2,113 KB
• 刊物主题：Veterinary Medicine; Zoology; Transgenics;
• 出版者：BioMed Central
• ISSN：1746-6148

文摘

Background Listeria monocytogenes (LM), a foodborne pathogen, can cause pregnancy failure in animals, especially in ruminants. Recent studies have shown that LM activates inflammasomes to induce IL-1β release in macrophages, however, whether the inflammasome activation regulates LM-induced pregnancy failure remains largely unknown. Here we used mouse model to investigate the molecular mechanism by which LM-induced inflammsome activation contributes to LM-associated pregnancy failure