Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery
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- 作者：Li Li (1)
Wenyi Gu (1)
Jian Liu (2)
Shiyu Yan (1)
Zhi Ping Xu (1)
1. Australian Institute for Bioengineering and Nanotechnology ; The University of Queensland ; Brisbane ; QLD ; 4072 ; Australia
2. Department of Chemical Engineering ; Curtin University ; Perth ; WA ; 6845 ; Australia - 关键词：layered double hydroxide ; (LDH) ; functionalization ; self ; assembly ; gene delivery
- 刊名：Nano Research
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：8
- 期：2
- 页码：682-694
- 全文大小：2,014 KB
- 参考文献：1. Tan, S. J.; Kiatwuthinon, P.; Roh, Y. H.; Kahn, J. S.; Luo, D. Engineering nanocarriers for siRNA delivery. / Small 2011, / 7, 841鈥?56. CrossRef
2. Davis, M. E.; Zuckerman, J. E.; Choi, C. H. J.; Seligson, D.; Tolcher, A.; Alabi, C. A.; Yen, Y.; Heidel, J. D.; Ribas, A. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. / Nature 2010, / 464, 1067鈥?070. CrossRef
3. Oh, Y. K.; Park, T. G. siRNA delivery systems for cancer treatment. / Adv. Drug Delivery Rev. 2009, / 61, 850鈥?62. CrossRef
4. Elbashir, S. M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. / Nature 2001, / 411, 494鈥?98. CrossRef
5. Chen, M.; Cooper, H. M.; Zhou, J. Z.; Bartlett, P. F.; Xu, Z. P. Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of sirna delivery. / J. Colloid Interface Sci. 2013, / 390, 275鈥?81. CrossRef
6. Tseng, Y. C.; Mozumdar, S.; Huang, L. Lipid-based systemic delivery of siRNA. / Adv. Drug Delivery Rev. 2009, / 61, 721鈥?31. CrossRef
7. Li, J.; Wang, Y.; Zhu, Y.; Oupick媒, D. Recent advances in delivery of drug-nucleic acid combinations for cancer treatment. / J. Controlled Release 2013, / 172, 589鈥?00. CrossRef
8. Tang, F.; Li, L.; Chen, D. Mesoporous silica nanoparticles: Synthesis, biocompatibility and drug delivery. / Adv. Mater. 2012, / 24, 1504鈥?534. CrossRef
9. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. / Nat. Nanotechnol. 2007, / 2, 751鈥?60. CrossRef
10. Ladewig, K.; Niebert, M.; Xu, Z. P.; Gray, P. P.; Lu, G. Q. M. Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles. / Biomaterials 2010, / 31, 1821鈥?829. CrossRef
11. Chang, R. S.; Suh, M. S.; Kim, S.; Shim, G.; Lee, S.; Han, S. S.; Lee, K. E.; Jeon, H.; Choi, H. G.; Choi, Y. et al. Cationic drug-derived nanoparticles for multifunctional delivery of anticancer sirna. / Biomaterials 2011, / 32, 9785鈥?795. CrossRef
12. Xu, Z. P.; Niebert, M.; Porazik, K.; Walker, T. L.; Cooper, H. M.; Middelberg, A. P. J.; Gray, P. P.; Bartlett, P. F.; Lu, G. Q. Subcellular compartment targeting of layered double hydroxide nanoparticles. / J. Controlled Release 2008, / 130, 86鈥?4. CrossRef
13. Ladewig, K.; Xu, Z. P.; Lu, G. Q. Layered double hydroxide nanoparticles in gene and drug delivery. / Expert Opin. Drug Delivery 2009, / 6, 907鈥?22. CrossRef
14. Khan, A. I.; Ragavan, A.; Fong, B.; Markland, C.; O鈥橞rien, M.; Dunbar, T. G.; Williams, G. R.; O鈥橦are, D. Recent developments in the use of layered double hydroxides as host materials for the storage and triggered release of functional anions. / Ind. Eng. Chem. Res. 2009, / 48, 10196鈥?0205. CrossRef
15. Choi, S. J.; Choy, J. H. Layered double hydroxide nanoparticles as target-specific delivery carriers: Uptake mechanism and toxicity. / Nanomedicine 2011, / 6, 803鈥?14. CrossRef
16. Wong, Y.; Markham, K.; Xu, Z. P.; Chen, M.; Lu, G. Q.; Bartlett, P. F.; Cooper, H. M. Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles. / Biomaterials 2010, / 31, 8770鈥?779. CrossRef
17. Wong, Y. Y.; Cooper, H. M.; Zhang, K.; Chen, M.; Bartlett, P.; Xu, Z. P. Efficiency of layered double hydroxide nanoparticle-mediated delivery of siRNA is determined by nucleotide sequence. / J. Colloid Interface Sci. 2012, / 369, 453鈥?59. CrossRef
18. Choi, S. J.; Oh, J. M.; Choy, J. H. Anticancer drug-layered hydroxide nanohybrids as potent cancer chemotherapy agents. / J. Phys. Chem. Solids 2008, / 69, 1528鈥?532. CrossRef
19. Sakurai, Y.; Hatakeyama, H.; Sato, Y.; Akita, H.; Takayama, K.; Kobayashi, S.; Futaki, S.; Harashima, H. Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA. / Biomaterials 2011, / 32, 5733鈥?742. CrossRef
20. Taratula, O.; Kuzmov, A.; Shah, M.; Garbuzenko, O. B.; Minko, T. Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA. / J. Controlled Release 2013, / 171, 349鈥?57. CrossRef
21. Oh, J. M.; Choi, S. J.; Lee, G. E.; Han, S. H.; Choy, J. H. Inorganic drug-delivery nanovehicle conjugated with cancer-cell-specific ligand. / Adv. Funct. Mater. 2009, / 19, 1617鈥?624. CrossRef
22. Zhu, Y.; Li, Z.; Chen, M.; Cooper, H. M.; Lu, G. Q.; Xu, Z. P. Synthesis of robust sandwich-like SiO2@CdTe@SiO2 fluorescent nanoparticles for cellular imaging. / Chem. Mater. 2012, / 24, 421鈥?23. CrossRef
23. Shao, M. F.; Ning, F. Y.; Zhao, J. W.; Wei, M.; Evans, D. G.; Duan, X. Preparation of Fe3O4@SiO2@layered double hydroxide core-shell microspheres for magnetic separation of proteins. / J. Am. Chem. Soc. 2012, / 134, 1071鈥?077. CrossRef
24. Du, X. J.; Zhang, D. S.; Gao, R. H.; Huang, L.; Shi, L. Y.; Zhang, J. P. Design of modular catalysts derived from NiMgAl-LDH@m-SiO2 with dual confinement effects for dry reforming of methane. / Chem. Commun. 2013, / 49, 6770鈥?772. CrossRef
25. Liu, J.; Harrison, R.; Zhou, J. Z.; Liu, T. T.; Yu, C.; Lu, G. Q.; Qiao, S. Z.; Xu, Z. P. Synthesis of nanorattles with layered double hydroxide core and mesoporous silica shell as delivery vehicles. / J. Mater. Chem. 2011, / 21, 10641鈥?0644. CrossRef
26. Gary-Bobo, M.; Hocine, O.; Brevet, D.; Maynadier, M.; Raehm, L.; Richeter, S.; Charasson, V.; Loock, B.; Mor猫re, A.; Maillard, P. et al. Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT. / Int. J. Pharm. 2012, / 423, 509鈥?15. CrossRef
27. Roesch, A.; Vultur, A.; Bogeski, I.; Wang, H.; Zimmermann, K. M.; Speicher, D.; K枚rbel, C.; Laschke, M. W.; Gimotty, P. A.; Philipp, S. E. et al. Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1Bhigh cells. / Cancer Cell 2013, / 23, 811鈥?25. CrossRef
28. Rosenholm, J. M.; Sahlgren, C.; Linden, M. Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-opportunities & challenges. / Nanoscale 2010, / 2, 1870鈥?883. CrossRef
29. Gu, W. Y.; Jia, Z. F.; Truong, N. P.; Prasadam, I.; Xiao, Y.; Monteiro, M. J. Polymer nanocarrier system for endosome escape and timed release of sirna with complete gene silencing and cell death in cancer cells. / Biomacromolecules 2013, / 14, 3386鈥?389. CrossRef
30. Xu, Z. P.; Stevenson, G.; Lu, C. Q.; Lu, G. Q.; Bartlett, P. F.; Gray, P. Stable suspension of layered double hydroxide nanoparticles in aqueous solution. / J. Am. Chem. Soc. 2006, / 128, 36鈥?7. CrossRef
31. Yokoi, T.; Sakamoto, Y.; Terasaki, O.; Kubota, Y.; Okubo, T.; Tatsumi, T. Periodic arrangement of silica nanospheres assisted by amino acids. / J. Am. Chem. Soc. 2006, / 128, 13664鈥?3665. CrossRef
32. Li, L.; Gu, W. Y.; Chen, J. Z.; Chen, W. Y.; Xu, Z. P. Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. / Biomaterials 2014, / 35, 3331鈥?339. CrossRef
33. Hartlen, K. D.; Athanasopoulos, A. P. T.; Kitaev, V. Facile preparation of highly monodisperse small silica spheres (15 to >200 nm) suitable for colloidal templating and formation of ordered arrays. / Langmuir 2008, / 24, 1714鈥?720. CrossRef
34. Xu, Z. P.; Stevenson, G.; Lu, C. Q.; Lu, G. Q. Dispersion and size control of layered double hydroxide nanoparticles in aqueous solutions. / J. Phys. Chem. 2006, / 110, 16923鈥?6929. CrossRef
35. Gu, Z.; Thomas, A. C.; Xu, Z. P.; Campbell, J. H.; Lu, G. Q. / In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids. / Chem. Mater. 2008, / 20, 3715鈥?722. CrossRef
36. Mandel, K.; Drenkova-Tuhtan, A.; Hutter, F.; Gellermann, C.; Steinmetz, H.; Sextl, G. Layered double hydroxide ion exchangers on superparamagnetic microparticles for recovery of phosphate from waste water. / J. Mater. Chem. 2013, / 1, 1840鈥?848. CrossRef
37. Hartono, S. B.; Gu, W. Y.; Kleitz, F.; Liu, J.; He, L. Z.; Middelberg, A. P. J.; Yu, C. Z.; Lu, G. Q.; Qiao, S. Z. Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery. / ACS Nano 2012, / 6, 2104鈥?117. CrossRef
38. Yu, C.; Chu, H.; Wan, Y.; Zhao, D. Synthesis of easily shaped ordered mesoporous titanium-containing silica. / J. Mater. Chem. 2010, / 20, 4705鈥?714. CrossRef
39. Mishra, M.; Das, M.; Goswamee, R. Synthesis and coating of silica supported nickel oxide particles over ceramic pre-forms through sol-gel derived layered double hydroxides. / J. Sol-Gel Sci. Technol. 2010, / 54, 57鈥?1. CrossRef
40. Choi, S. J.; Oh, J. M.; Park, T.; Choy, J. H. Cellular toxicity of inorganic hydroxide nanoparticles. / J. Nanosci. Nanotechnol. 2007, / 7, 4017鈥?020. CrossRef
41. Slowing, I. I.; Wu, C. W.; Vivero-Escoto, J. L.; Lin, V. S. Y. Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells. / Small 2009, / 5, 57鈥?2. CrossRef
42. Yu, T.; Malugin, A.; Ghandehari, H. Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. / ACS Nano 2011, / 5, 5717鈥?728. CrossRef
43. Paula, A. J.; Martinez, D. S. T.; Araujo J煤nior, R. T.; Souza Filho, A. G.; Alves, O. L. Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: Independence of the surface microchemical environment. / J. Braz. Chem. Soc. 2012, / 23, 1807鈥?814. CrossRef
44. Gu, J.; Su, S.; Li, Y.; He, Q.; Shi, J. Hydrophilic mesoporous carbon nanoparticles as carriers for sustained release of hydrophobic anti-cancer drugs. / Chem. Commun. 2011, / 47, 2101鈥?103. CrossRef
45. Truong, N. P.; Gu, W.; Prasadam, I.; Jia, Z.; Crawford, R.; Xiao, Y.; Monteiro, M. J. An influenza virus-inspired polymer system for the timed release of sirna. / Nat. Commun. 2013, / 4, 1902. CrossRef - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chinese Library of Science
Chemistry
Nanotechnology - 出版者：Tsinghua University Press, co-published with Springer-Verlag GmbH
- ISSN：1998-0000
文摘
In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposite (NH2-SiO2@LDH) via electrostatic interactions and condensation of (3-aminopropyl)triethoxysilane (APTES). This nanocomposite system is well dispersed in culture media and phosphate buffered saline, and exhibits low cytotoxicity and good biocompatibility. The fluorescence microscopy images and flow cytometry data indicate that such an NH2-SiO2@LDH nanocomposite is able to efficiently deliver small interfering RNA (siRNA) into the U2OS cell line to inhibit cell proliferation. Thus, NH2-SiO2@LDH nanocomposite has a great potential as a nanocarrier for efficient gene delivery.