Phototransformation of mefenamic acid induced by nitrite ions in water: mechanism, toxicity, and degradation pathways

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• 作者：Ping Chen ; Wenying Lv ; Zhiming Chen…
• 关键词：Mefenamic acid ; Hydroxyl radical ; Photo ; induced degradation ; Toxicity ; Photodegradation pathway ; UV
• 刊名：Environmental Science and Pollution Research
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：22
• 期：16
• 页码：12585-12596
• 全文大小：647 KB
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• 作者单位：Ping Chen (1)
  Wenying Lv (1)
  Zhiming Chen (1)
  Jingshuai Ma (1)
  Ruobai Li (1)
  Kun Yao (1)
  Guoguang Liu (1)
  Fuhua Li (1)
  
  1. School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, People’s Republic of China
  
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment
  Environment
  Atmospheric Protection, Air Quality Control and Air Pollution
  Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
  Industrial Pollution Prevention
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1614-7499

文摘

Here, we evidenced the photo-induced degradation of mefenamic acid, a nonsteroidal anti-inflammatory drug, through the 254-nm light excitation of nitrite. The results demonstrated that the photodegradation of mefenamic acid was enhanced, and the mefenamic acid photodegradation rate significantly increased, from 0.00627 to 0.0350?min? as the nitrite was increased from 0 to 0.5?mmol?L?. The photodegradation rate increased from 0.0287 to 0.0512?min? as the pH was elevated, from 5.0 to 10.0. The actual second-order rate constant for the reaction of mefenamic acid with ·OH was investigated to 1.079?×-010?M??s? according to steady-state ·OH concentration of 3.5?×-0?4?mmol?L? and the contribution to the rate of ·OH of 67.1?%. The photoproducts were identified using HPLC/MS/MS, and possible nitrite-induced photodegradation pathways were proposed by hydroxylation, dehydrogenation, hydration, nitrosylation, and ketonized reactions. The toxicity of the phototransformation products was evaluated using the Microtox test, which revealed that the photoproducts were more toxic than mefenamic acid for the generation of nitrosation aromatic compounds.