The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease: A Pilot Study
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- 作者：David Tendler ; Sauyu Lin ; William S. Yancy ; John Mavropoulos ; Pam Sylvestre ; Don C. Rockey and Eric C. Westman
- 关键词：Nonalcoholic fatty liver disease ; NASH ; Low ; carbohydrate ketogenic diet ; Cirrhosis ; Fatty liver
- 刊名：Digestive Diseases and Sciences
- 出版年：2007
- 出版时间：February, 2007
- 年：2007
- 卷：52
- 期：2
- 页码：589-593
- 全文大小：178 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Gastroenterology
Hepatology
Oncology
Transplant Surgery
Biochemistry - 出版者：Springer Netherlands
- ISSN：1573-2568
文摘
Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m2 and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of carbohydrate) with nutritional supplementation for 6 months. Patients returned for group meetings biweekly for 3 months, then monthly for the second 3 months. The mean weight change was −12.8 kg (range 0 to −25.9 kg). Four of 5 posttreatment liver biopsies showed histologic improvements in steatosis (P=.02) inflammatory grade (P=.02), and fibrosis (P=.07). Six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease. Further research is into this approach is warranted.