The Effect of A2A Adenosine Receptor Activation on C-C Chemokine Receptor 7 Expression in Human THP1 Macrophages During Inflammation

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• 作者：Adrienne J. Williams (1)
  Bruce N. Cronstein (12) Bruce.Cronstein@nyuMc.org
• 关键词：KEY WORDS A2A adenosine receptor – ; macrophage – ; chemokine receptor migration
• 刊名：Inflammation
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：35
• 期：2
• 页码：614-622
• 全文大小：397.9 KB
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• 作者单位：1. Division of Translational Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA2. Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

C-C chemokine receptor 7 (CCR7) and its chemoattractant agonist CCL21 promote cell migration and expression of pro-inflammatory proteins in an atherogenic environment. Since A_2A adenosine receptor activation reduces migration and inflammatory effects, we examined its effect on CCR7 expression and migration. CCR7 protein expression decreased by about a third in macrophages treated with A_2A receptor agonist CGS 21680 (p = 0.028, n = 7) and was reversed with antagonist, although mRNA levels increased twofold (p = 0.001, n = 3). Furthermore, macrophages treated with CGS 21680 showed a significant decrease in migration (p = 0.0311, n = 7). These results suggest that A_2A adenosine receptor activation not only modulates CCR7 expression in both normal and inflammatory environments but also regulates macrophage migration to CCR7-specific chemoattractants.