Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

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• 作者：Chen Li (5)
  Zhuan-Hua Wang (5)
  Deng-Guang Yu (6)
  Gareth R Williams (7)
  
  5. Key Laboratory of Chemical Biology and Molecular Engineering ; College of Life Science ; Shanxi University ; 92 Wucheng Road ; Taiyuan ; 030006 ; China
  6. School of Materials Science & Engineering ; University of Shanghai for Science and Technology ; Shanghai ; 200093 ; China
  7. Upalitocacy ; 29-39 Brunswick Square ; London ; WC1N 1AX ; UK
  
• 关键词：Modified coaxial electrospinning ; Core ; shell nanofibers ; Tunable biphasic release ; PVC ; coated spinneret ; Ethyl cellulose
• 刊名：Nanoscale Research Letters
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：9
• 期：1
• 全文大小：784 KB
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• 刊物主题：Nanotechnology; Nanotechnology and Microengineering; Nanoscale Science and Technology; Nanochemistry; Molecular Medicine;
• 出版者：Springer US
• ISSN：1556-276X

文摘

This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and core parts of the nanofibers, respectively. Scanning and transmission electron microscopy demonstrated that the nanofibers had linear morphologies and core-shell structures. The quercetin was found to be present in the nanofibers in the amorphous physical status, on the basis of X-ray diffraction results. In vitro release profiles showed that the PVP shell very rapidly freed its drug cargo into the solution, while the EC core provided the succedent sustained release. Variation of the drug loading permitted the release profiles to be tuned.