Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans
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- 作者：Jaclyn Ellis (1)
Ethan M. Lange (1) (2)
Jin Li (1)
Josee Dupuis (3) (4)
Jens Baumert (5)
Jeremy D. Walston (6)
Brendan J. Keating (7)
Peter Durda (8)
Ervin R. Fox (9)
Cameron D. Palmer (10) (11)
Yan A. Meng (10)
Taylor Young (10)
Deborah N. Farlow (10)
Renate B. Schnabel (12)
Carola S. Marzi (5)
Emma Larkin (13)
Lisa W. Martin (14)
Joshua C. Bis (15)
Paul Auer (16)
Vasan S. Ramachandran (17)
Stacey B. Gabriel (10)
Monte S. Willis (18)
James S. Pankow (19)
George J. Papanicolaou (20)
Jerome I. Rotter (21) (22) (23)
Christie M. Ballantyne (24)
Myron D. Gross (25)
Guillaume Lettre (26) (27)
James G. Wilson (9)
Ulrike Peters (28)
Wolfgang Koenig (29)
Russell P. Tracy (8)
Susan Redline (30)
Alex P. Reiner (31)
Emelia J. Benjamin (3) (32)
Leslie A. Lange (1) - 刊名：Human Genetics
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：133
- 期：8
- 页码：985-995
- 全文大小：266 KB
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Ethan M. Lange (1) (2)
Jin Li (1)
Josee Dupuis (3) (4)
Jens Baumert (5)
Jeremy D. Walston (6)
Brendan J. Keating (7)
Peter Durda (8)
Ervin R. Fox (9)
Cameron D. Palmer (10) (11)
Yan A. Meng (10)
Taylor Young (10)
Deborah N. Farlow (10)
Renate B. Schnabel (12)
Carola S. Marzi (5)
Emma Larkin (13)
Lisa W. Martin (14)
Joshua C. Bis (15)
Paul Auer (16)
Vasan S. Ramachandran (17)
Stacey B. Gabriel (10)
Monte S. Willis (18)
James S. Pankow (19)
George J. Papanicolaou (20)
Jerome I. Rotter (21) (22) (23)
Christie M. Ballantyne (24)
Myron D. Gross (25)
Guillaume Lettre (26) (27)
James G. Wilson (9)
Ulrike Peters (28)
Wolfgang Koenig (29)
Russell P. Tracy (8)
Susan Redline (30)
Alex P. Reiner (31)
Emelia J. Benjamin (3) (32)
Leslie A. Lange (1)
1. Department of Genetics, University of North Carolina, 5112 Genetic Medicine Bldg., Chapel Hill, NC, 27599-7264, USA
2. Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 27599, USA
3. National Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, 01702, USA
4. Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
5. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 23538, Neuherberg, Germany
6. Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
7. Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
8. Departments of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, VT, 05405, USA
9. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA
10. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, 02142, USA
11. Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital Boston, Boston, MA, 02115, USA
12. Department of General and Interventional Cardiology, University Heart Center Hamburg, 21046, Hamburg, Germany
13. Division of Allergy, Pulmonary and Critical Care, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
14. Division of Cardiology, George Washington School of Medicine, Washington, DC, 20037, USA
15. Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, WA, 98101, USA
16. School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53206, USA
17. Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA
18. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA
19. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, 55455, USA
20. Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD, 20892, USA
21. Departments of Pediatrics, Medicine, and Human Genetics, University of California, Los Angeles, CA, 90095, USA
22. Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA
23. Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA, USA
24. Section of Cardiovascular Research, Baylor College of Medicine, Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, TX, 77030, USA
25. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA
26. Montréal Heart Institute, Montréal, H3A 2T5, Canada
27. Département de Médecine, Université de Montréal, Montréal, H3A 2T5, Canada
28. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
29. Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, 07304, Ulm, Germany
30. Department of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston, MA, USA
31. Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA
32. Department of Epidemiology, Boston University School of Public Health, Boston, MA, 02118, USA - ISSN：1432-1203
文摘
C-reactive protein (CRP) is a heritable biomarker of systemic inflammation and a predictor of cardiovascular disease (CVD). Large-scale genetic association studies for CRP have largely focused on individuals of European descent. We sought to uncover novel genetic variants for CRP in a multiethnic sample using the ITMAT Broad-CARe (IBC) array, a custom 50,000 SNP gene-centric array having dense coverage of over 2,000 candidate CVD genes. We performed analyses on 7,570 African Americans (AA) from the Candidate gene Association Resource (CARe) study and race-combined meta-analyses that included 29,939 additional individuals of European descent from CARe, the Women’s Health Initiative (WHI) and KORA studies. We observed array-wide significance (p??) for four loci in AA, three of which have been reported previously in individuals of European descent (IL6R, p?=?2.0?×?10?; CRP, p?=?4.2?×?10?1; APOE, p?=?1.6?×?10?). The fourth significant locus, CD36 (p?=?1.6?×?10?), was observed at a functional variant (rs3211938) that is extremely rare in individuals of European descent. We replicated the CD36 finding (p?=?1.8?×?10?) in an independent sample of 8,041 AA women from WHI; a meta-analysis combining the CARe and WHI AA results at rs3211938 reached genome-wide significance (p?=?1.5?×?10?0). In the race-combined meta-analyses, 13 loci reached significance, including ten (CRP, TOMM40/APOE/APOC1, HNF1A, LEPR, GCKR, IL6R, IL1RN, NLRP3, HNF4A and BAZ1B/BCL7B) previously associated with CRP, and one (ARNTL) previously reported to be nominally associated with CRP. Two novel loci were also detected (RPS6KB1, p?=?2.0?×?10?; CD36, p?=?1.4?×?10?). These results highlight both shared and unique genetic risk factors for CRP in AA compared to populations of European descent.