Ekkrines Adenokarzinom bei einer Patientin mit famili?rem Mammakarzinom
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- 作者：M. Wosnitza (1)
A. Rübben (1)
N. Pallua (2)
M. Megahed (1) - 关键词：Ekkrines Adenokarzinom ; Schwei?drüsentumor ; Tamoxifen ; Eccrine adenocarcinoma ; Sweat gland tumor ; Tamoxifen
- 刊名：Der Hautarzt
- 出版年：2008
- 出版时间：November 2008
- 年：2008
- 卷：59
- 期：11
- 页码：879-883
- 全文大小：608KB
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12. Hiatt KM, Pillow JL, Smoller BR (2004) Her-2 expression in cutaneous eccrine and apocrine neoplasms. Mod Pathol 17: 28-2 10.1038/modpathol.3800007">CrossRef - 作者单位：M. Wosnitza (1)
A. Rübben (1)
N. Pallua (2)
M. Megahed (1)
1. Klinik für Allergologie und Dermatologie, Universit?tsklinikum RWTH Aachen, Pauwelsstra?e 30, 52074, Aachen, Deutschland
2. Klinik für Plastische Chirurgie, Hand- und Verbrennungschirurgie, Universit?tsklinikum der RWTH Aachen, Aachen, Deutschland - ISSN：1432-1173
文摘
A 67-year-old patient developed a subcutaneous, non-tender nodule in her left groin over a period of about seven years. The patient underwent surgery and 4 procedures were required to obtain complete excision. The histopathologic findings showed eccrine adenocarcinoma, a member of the heterogeneous group of sweat gland tumors which occur primarily in adults with a peak of 50-0 years of age. Sweat gland carcinomas are extremely rare neoplasms of the skin and exhibit a slow growth rate with a rather high local recurrence rate. The tumor has a disposition to metastasize and shows a poor response rate to adjuvant therapy regimens. Therefore wide, deep surgical excision with an excision margin of 2-?cm is the treatment of choice. Nevertheless there are some case reports on successful therapy of a metastasized sweat gland carcinoma with 5-fluorouracil and tamoxifen. Here further studies are needed to achieve a better survival rate for patients with metastatic disease.