The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?

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• 作者：Cheng Huang ; Xiang-Hui Fu ; Dong Zhou ; Jin-Mei Li
• 关键词：Adult neurogenesis ; Epilepsy ; Epileptogenesis ; Dentate gyrus ; Hippocampus ; Wnt/β ; catenin signaling pathway
• 刊名：Neurochemical Research
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：40
• 期：7
• 页码：1319-1332
• 全文大小：931 KB
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• 作者单位：Cheng Huang (1) (2)
  Xiang-Hui Fu (2)
  Dong Zhou (1)
  Jin-Mei Li (1)
  
  1. Department of Neurology, West China Hospital, Sichuan University, 37th Guoxue Allay, Chengdu, 610041, People’s Republic of China
  2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, No.17 South Renmin Road Section?3, Chengdu, 610041, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Biochemistry
  Neurology
  
• 出版者：Springer Netherlands
• ISSN：1573-6903

文摘

Temporal lobe epilepsy is one of the most common clinical neurological disorders. One of the major pathological findings in temporal lobe epilepsy is hippocampal sclerosis, characterized by massive neuronal loss and severe gliosis. The epileptogenesis process of temporal lobe epilepsy usually starts with initial precipitating insults, followed by neurodegeneration, abnormal hippocampus circuitry reorganization, and the formation of hypersynchronicity. Experimental and clinical evidence strongly suggests that dysfunctional neurogenesis is involved in the epileptogenesis. Recent data demonstrate that neurogenesis is induced by acute seizures or precipitating insults, whereas the capacity of neuronal recruitment and proliferation substantially decreases in the chronic phase of epilepsy. Participation of the Wnt/β-catenin signaling pathway in neurogenesis reveals its importance in epileptogenesis; its dysfunction contributes to the structural and functional abnormality of temporal lobe epilepsy, while rescuing this pathway exerts neuroprotective effects. Here, we summarize data supporting the involvement of Wnt/β-catenin signaling in the epileptogenesis of temporal lobe epilepsy. We also propose that the Wnt/β-catenin signaling pathway may serve as a promising therapeutic target for temporal lobe epilepsy treatment.