SIV Infection Impairs the Central Nervous System in Chinese Rhesus Macaques

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• 作者：Hang Liu ; Qian-Hao Xiao ; Jin-Biao Liu ; Jie-Liang Li…
• 刊名：Journal of Neuroimmune Pharmacology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：11
• 期：3
• 页码：592-600
• 全文大小：2,038 KB
• 刊物主题：Neurosciences; Immunology; Pharmacology/Toxicology; Virology; Cell Biology;
• 出版者：Springer US
• ISSN：1557-1904
• 卷排序：11

文摘

The central nervous system (CNS) impairment is a consequence seen in SIV infection of rhesus macaques of Indian-origin, which is more common in infected macaques with rapid disease progression than in those with conventional disease progression. Here, we investigated the CNS damages in SIVmac239-infected Chinese rhesus macaques. We demonstrated that SIV infection of Chinese macaques could cause neuropathological impairments, which was evidenced by appearance of SIV-RNA positive cells, the infiltration of activated macrophages and abundant multinucleated giant cells (MNGCs) in the different regions of the brains. The animals with high viremia and short survival time (average of 16 weeks, rapid progression, RP) had severer neuropathological changes than those with conventional progression (CP). As compared with the RP animals, CP macaques had lower viremia and much longer survival time (average of 154 weeks). These findings indicate that SIVmac239 infection of Chinese rhesus macaque can be used as a suitable animal model and alternative resource for nueroAIDS research.KeywordsSIVmac239Chinese rhesus macaqueNeuropathological lesionRapid progressionNeuroAIDS