Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice
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- 作者：Xiaochun Xia ; Yang Li ; Qiang Su ; Zhengrong Huang ; Yuemao Shen…
- 关键词：Mycoepoxydiene ; ox ; LDL ; Macrophage ; Foam cell ; Atherosclerosis
- 刊名：Cell & Bioscience
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：5
- 期：1
- 全文大小：1,580 KB
- 刊物主题：Cell Biology; Microbiology;
- 出版者：BioMed Central
- ISSN：2045-3701
文摘
Background Mycoepoxydiene (MED) is a polyketide that can be isolated from a marine fungus and is associated with various activities, including antitumor and anti-inflammatory functions. However, its effects on atherosclerosis remain unknown. Macrophage-derived foam cells play crucial roles in the initiation and progression of atherosclerotic plaques. In this study, we investigated the effects of MED on oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and activation, and on high fat diet (HFD)-induced atherosclerosis in ApoE-deficient (ApoE −/− ) mice.