The Expression Changes of Myelin and Lymphocyte Protein (MAL) Following Optic Nerve Crush in Adult Rats Retinal Ganglion Cells
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- 作者：Yongsheng Huang (1)
Yue Xu (1)
Qiaochu Cheng (1)
Shanshan Yu (1)
Yi Gao (1)
Qinmeng Shu (2)
Cheng Yang (3)
Yuan Sun (1)
Jiawei Wang (1)
Fan Xu (1)
Xiaoling Liang (1) - 关键词：Optic nerve crush ; MAL ; Retinal ganglion cells ; Apoptosis ; Rats
- 刊名：Journal of Molecular Neuroscience
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：54
- 期：4
- 页码：614-621
- 全文大小：2,175 KB
- 参考文献：1. Allcutt D, Berry M, Sievers J (1984) A qualitative comparison of the reactions of retinal ganglion cell axons to optic nerve crush in neonatal and adult mice. Brain Res 318:231鈥?40 CrossRef
2. Alonso MA, Millan J (2001) The role of lipid rafts in signalling and membrane trafficking in T lymphocytes. J Cell Sci 114:3957鈥?965
3. Alonso MA, Weissman SM (1987) cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. Proc Natl Acad Sci U S A 84:1997鈥?001 CrossRef
4. Boatright KM, Salvesen GS (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15:725鈥?31 CrossRef
5. Bouchard VJ, Rouleau M, Poirier GG (2003) PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31:446鈥?54 CrossRef
6. Buffart TE, Overmeer RM, Steenbergen RD, Tijssen M, van Grieken NC, Snijders PJ, Grabsch HI, van de Velde CJ, Carvalho B, Meijer GA (2008) MAL promoter hypermethylation as a novel prognostic marker in gastric cancer. Br J Cancer 99:1802鈥?807 CrossRef
7. Cao W, Zhang ZY, Xu Q, Sun Q, Yan M, Zhang J, Zhang P, Han ZG, Chen WT (2010) Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma. Mol Cancer 9:296 CrossRef
8. Castano A, Bell MD, Perry VH (1996) Unusual aspects of inflammation in the nervous system: Wallerian degeneration. Neurobiol Aging 17:745鈥?51 CrossRef
9. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403:434鈥?39 CrossRef
10. Fischer D, Pavlidis M, Thanos S (2000) Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture. Invest Ophthalmol Vis Sci 41:3943鈥?954
11. Frank M (2000) MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond. Prog Neurobiol 60:531鈥?44 CrossRef
12. Frank M, van der Haar ME, Schaeren-Wiemers N, Schwab ME (1998) rMAL is a glycosphingolipid-associated protein of myelin and apical membranes of epithelial cells in kidney and stomach. J Neurosci 18:4901鈥?913
13. Goldenberg-Cohen N, Dratviman-Storobinsky O, El Dadon Bar S, Cheporko Y, Hochhauser E (2011) Protective effect of Bax ablation against cell loss in the retinal ganglion layer induced by optic nerve crush in transgenic mice. J Neuroophthalmol 31:331鈥?38 CrossRef
14. GrandPre T, Nakamura F, Vartanian T, Strittmatter SM (2000) Identification of the Nogo inhibitor of axon regeneration as a reticulon protein. Nature 403:439鈥?44 CrossRef
15. Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR (2011) Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One 6:e17659 CrossRef
16. Gupta VK, You Y, Li JC, Klistorner A, Graham SL (2013) Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. J Mol Neurosci 49:96鈥?04 CrossRef
17. Horne HN, Lee PS, Murphy SK, Alonso MA, Olson JA Jr, Marks JR (2009) Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. Mol Cancer Res 7:199鈥?09 CrossRef
18. Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z (2012) Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron 73:445鈥?52 CrossRef
19. Joachim SC, Mondon C, Gramlich OW, Grus FH, Dick HB (2014) Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions. J Mol Neurosci 52:216鈥?24 CrossRef
20. Katai N, Yoshimura N (1999) Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases. Invest Ophthalmol Vis Sci 40:2697鈥?705
21. Kermer P, Klocker N, Labes M, Thomsen S, Srinivasan A, Bahr M (1999) Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo. FEBS Lett 453:361鈥?64 CrossRef
22. Kim T, Fiedler K, Madison DL, Krueger WH, Pfeiffer SE (1995) Cloning and characterization of MVP17: a developmentally regulated myelin protein in oligodendrocytes. J Neurosci Res 42:413鈥?22 CrossRef
23. Krupinski J, Ferrer I, Barrachina M, Secades JJ, Mercadal J, Lozano R (2002) CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. Neuropharmacology 42:846鈥?54 CrossRef
24. Kwon KB, Yoo SJ, Ryu DG, Yang JY, Rho HW, Kim JS, Park JW, Kim HR, Park BH (2002) Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem Pharmacol 63:41鈥?7 CrossRef
25. Leung CK, Lindsey JD, Crowston JG, Lijia C, Chiang S, Weinreb RN (2008) Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci 49:4898鈥?902 CrossRef
26. Li Y, Schlamp CL, Nickells RW (1999) Experimental induction of retinal ganglion cell death in adult mice. Invest Ophthalmol Vis Sci 40:1004鈥?008
27. Li A, Zou F, Fu H, Cui G, Yan Y, Wu Q, Gu X (2013) Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats. J Mol Neurosci 51:208鈥?18 CrossRef
28. Mao H, Liu J, Shi W, Huang Q, Xu X, Ni L, Zou F, Shi J, Li D, Liu Y, Chen J (2013) The expression patterns of septin-9 after traumatic brain injury in rat brain. J Mol Neurosci 51:558鈥?66 CrossRef
29. Mimori K, Shiraishi T, Mashino K, Sonoda H, Yamashita K, Yoshinaga K, Masuda T, Utsunomiya T, Alonso MA, Inoue H, Mori M (2003) MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway. Oncogene 22:3463鈥?471 CrossRef
30. Nadal-Nicolas FM, Jimenez-Lopez M, Sobrado-Calvo P, Nieto-Lopez L, Canovas-Martinez I, Salinas-Navarro M, Vidal-Sanz M, Agudo M (2009) Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. Invest Ophthalmol Vis Sci 50:3860鈥?868 CrossRef
31. Neufeld AH, Liu B (2003) Glaucomatous optic neuropathy: when glia misbehave. Neuroscientist 9:485鈥?95 CrossRef
32. Overmeer RM, Henken FE, Bierkens M, Wilting SM, Timmerman I, Meijer CJ, Snijders PJ, Steenbergen RD (2009) Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis. J Pathol 219:327鈥?36 CrossRef
33. Parrilla-Reverter G, Agudo M, Sobrado-Calvo P, Salinas-Navarro M, Villegas-Perez MP, Vidal-Sanz M (2009) Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crush injury: a quantitative in vivo study. Exp Eye Res 89:32鈥?1 CrossRef
34. Quigley HA, McKinnon SJ, Zack DJ, Pease ME, Kerrigan-Baumrind LA, Kerrigan DF, Mitchell RS (2000) Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci 41:3460鈥?466
35. Rong X, Yang S, Miao H, Guo T, Wang Z, Shi W, Mo X, Yuan W, Jin T (2012) Effects of erythropoietin-dextran microparticle-based PLGA/PLA microspheres on RGCs. Invest Ophthalmol Vis Sci 53:6025鈥?034 CrossRef
36. Schaeren-Wiemers N, Schaefer C, Valenzuela DM, Yancopoulos GD, Schwab ME (1995a) Identification of new oligodendrocyte- and myelin-specific genes by a differential screening approach. J Neurochem 65:10鈥?2 CrossRef
37. Schaeren-Wiemers N, Valenzuela DM, Frank M, Schwab ME (1995b) Characterization of a rat gene, rMAL, encoding a protein with four hydrophobic domains in central and peripheral myelin. J Neurosci 15:5753鈥?764
38. Schaeren-Wiemers N, Bonnet A, Erb M, Erne B, Bartsch U, Kern F, Mantei N, Sherman D, Suter U (2004) The raft-associated protein MAL is required for maintenance of proper axon鈥攇lia interactions in the central nervous system. J Cell Biol 166:731鈥?42 CrossRef
39. Sharifi AM, Eslami H, Larijani B, Davoodi J (2009) Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett 459:47鈥?1 CrossRef
40. Shu Q, Xu Y, Zhuang H, Fan J, Sun Z, Zhang M, Xu G (2014) Ras homolog enriched in the brain is linked to retinal ganglion cell apoptosis after light injury in rats. J Mol Neurosci
41. Sucher NJ, Lipton SA, Dreyer EB (1997) Molecular basis of glutamate toxicity in retinal ganglion cells. Vis Res 37:3483鈥?493 CrossRef
42. Tezel G (2006) Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res 25:490鈥?13 CrossRef
43. Tsai RK, Chang CH, Sheu MM, Huang ZL (2010) Anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush are PI3K/AKT-dependent. Exp Eye Res 90:537鈥?45 CrossRef
44. van Wijk SJ, Hageman GJ (2005) Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic Biol Med 39:81鈥?0
45. Vigneswara V, Berry M, Logan A, Ahmed Z (2012) Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats. PLoS One 7:e53473 CrossRef
46. Wilson AM, Morquette B, Abdouh M, Unsain N, Barker PA, Feinstein E, Bernier G, Di Polo A (2013) ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. J Neurosci 33:2205鈥?216 CrossRef
47. Xu Y, Chen C, Jin N, Zhu J, Kang L, Zhou T, Wang J, Sheng A, Shi J, Gu Z, Sang A (2013a) Muller glia cells activation in rat retina after optic nerve injury: spatiotemporal correlation with transcription initiation factor IIb. J Mol Neurosci 51:37鈥?6 CrossRef
48. Xu Y, Yang L, Yu S, Shu Q, Yang C, Wang J, Xu F, Sang A, Liang X (2013) Spatiotemporal changes in NFATc4 expression of retinal ganglion cells after light-Induced damage. J Mol Neurosci
49. Xu Y, Yu S, Shu Q, Yang L, Yang C, Wang J, Xu F, Ji M, Liang X (2014) Upregulation of CREM-1 relates to retinal ganglion cells apoptosis after light-induced damage in vivo. J Mol Neurosci 52:331鈥?38 CrossRef
50. Zacchetti D, Peranen J, Murata M, Fiedler K, Simons K (1995) VIP17/MAL, a proteolipid in apical transport vesicles. FEBS Lett 377:465鈥?69 CrossRef
51. Zhang ZZ, Gong YY, Shi YH, Zhang W, Qin XH, Wu XW (2012) Valproate promotes survival of retinal ganglion cells in a rat model of optic nerve crush. Neuroscience 224:282鈥?93 CrossRef
52. Zhang J, Cui Z, Shen A, Li W, Xu G, Bao G, Sun Y, Wang L, Gu H, Zhou Y (2013) Upregulation of myelin and lymphocyte protein (MAL) after traumatic spinal cord injury in rats. J Mol Histol 44:125鈥?34 CrossRef
53. Zou F, Xu J, Fu H, Cao J, Mao H, Gong M, Cui G, Zhang Y, Shi W, Chen J (2013) Different functions of HIPK2 and CtBP2 in traumatic brain injury. J Mol Neurosci 49:395鈥?08 CrossRef - 作者单位：Yongsheng Huang (1)
Yue Xu (1)
Qiaochu Cheng (1)
Shanshan Yu (1)
Yi Gao (1)
Qinmeng Shu (2)
Cheng Yang (3)
Yuan Sun (1)
Jiawei Wang (1)
Fan Xu (1)
Xiaoling Liang (1)
1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong Province, People鈥檚 Republic of China
2. Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, People鈥檚 Republic of China
3. Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, People鈥檚 Republic of China - ISSN：1559-1166
文摘
Myelin and lymphocyte protein (MAL), a component of compact myelin, is highly expressed in oligodendrocytes and Schwann cells. It has been reported that MAL may play a vital role in the process of neuronal apoptosis following acute spinal cord injury. However, acquaintance regarding its distribution and possible function in the retina is limited. Therefore, in a rodent model of optic nerve crush (ONC), the dynamic changes of MAL in retina was detected. The expression of MAL was mainly located in the retinal ganglion cells (RGCs) and was increased strongly after ONC. The peak of MAL expression appeared on the third day. In addition, there was a concomitant upregulation of active-caspase-3, which also co-localized with MAL in RGCs. Moreover, co-localization of MAL with terminal deoxynucleotidyl transferase-mediated biotinylated-dUTP nick-end labeling (TUNEL) was detected in RGCs after ONC. Collectively, all these results suggested that the upregulation of MAL might play an important role in the pathophysiology of RGCs after ONC.