First way of enantioselective synthesis of moxifloxacin intermediate

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• 作者：GuangXun Li (1) (2)
  Lei Wu (1)
  QingQuan Fu (1)
  Zhuo Tang (1)
  XiaoMei Zhang (2)
  
• 关键词：enantioselective synthesis ; moxifloxacin intermediate ; (S ; S) ; 2 ; 8 ; diazobicyclo [4.3.0] nonane
• 刊名：SCIENCE CHINA Chemistry
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：56
• 期：3
• 页码：307-311
• 全文大小：511KB
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• 作者单位：GuangXun Li (1) (2)
  Lei Wu (1)
  QingQuan Fu (1)
  Zhuo Tang (1)
  XiaoMei Zhang (2)
  
  1. Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, 610041, China
  2. Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China
  
• ISSN：1869-1870

文摘

A new method of enantioselective synthesis of (S,S)-2,8-diazobicyclo [4.3.0] nonane was found by using (R)-2-amino-2- phenyl-ethanol as chiral induction reagent. The entire synthetic process included 8 steps which were easy to operate with high yield. The purification method was only simple recrystallization or even used directly in the next step without further purification. The total yield was 29%.