Ultrastructural effects of acetamizuril on endogenous phases of Eimeria tenella

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• 作者：Lili Liu ; Huiya Chen ; Chenzhong Fei ; Xiaoyang Wang ; Wenli Zheng…
• 关键词：Acetamizuril ; E. tenella ; Endogenous phase ; Ultrastructure
• 刊名：Parasitology Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：115
• 期：3
• 页码：1245-1252
• 全文大小：2,563 KB
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• 作者单位：Lili Liu (1)
  Huiya Chen (1)
  Chenzhong Fei (1)
  Xiaoyang Wang (1)
  Wenli Zheng (1)
  Mi Wang (1)
  Keyu Zhang (1)
  Lifang Zhang (1)
  Tao Li (1)
  Feiqun Xue (1)
  
  1. Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research, Chinese Academy of Agricultural Sciences, Shanghai Veterinary Research Institute, CAAS, No.518 Ziyue Rd, Minhang Dist., Shanghai, 200241, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Microbiology
  Immunology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1955

文摘

To explore the primary stage or site of action of acetamizuril (AZL), a novel triazine anticoccidial compound, the ultrastructural development of Eimeria tenella at different endogenous stages was studied in experimentally infected chickens treated with a single oral dose of 15 mg/kg AZL. As a result of drug action, the differentiations of second-generation schizonts and microgamonts were largely inhibited and merozoites became irregular in shape. Meanwhile, the outer membrane blistering and perinuclear space enlargement were obvious in the second-generation schizonts and microgamonts, which were never observed in the classic triazine anticoccidiosis drug diclazuril–treated E. tenella. The chromatin aggregation, anachromasis, and marginalization were visible in merozoites and microgamonts. Furthermore, the abnormal evagination of microgametes finally resulted in the degeneration of microgamonts and the failure of subsequent fertilization. The most marked micromorphological alteration occurring in the macrogamonts was the WFB2. Even if the fertilization occurred, the formation of oocyst wall became malformed and the zygote proceeded to the obvious degeneration. In addition, mitochondria swelling and cytoplasm vacuolization were discerned in respective intracellular stages, while endoplasmic reticulum and Golgi body swelling was less seen. These alterations may be the causes leading to the final death of E. tenella and also provide some information for further exploring the mechanism of action of AZL at the molecular level.