Protective effects of eplerenone on podocyte injury in adriamycin nephropathy rats
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- 作者：Zhan Fang (1) (2)
Chun Zhang (1)
Fangfang He (1)
Shan Chen (1)
Xifeng Sun (1)
Zhonghua Zhu (1)
Jianshe Liu (1)
Xianfang Meng (3) - 关键词：eplerenone ; adriamycin ; nephropathy ; podocyte ; TGF ; β1 ; desmin
- 刊名：Journal of Huazhong University of Science and Technology [Medical Sciences]
- 出版年：2011
- 出版时间：June 2011
- 年：2011
- 卷：31
- 期：3
- 页码：329-334
- 全文大小：884KB
- 参考文献：1. Nagase M, Fujita T. Aldosterone and glomerular podocyte injury. Clin Exp Nephrol, 2008,12(4):233-42 CrossRef
2. Kiyomoto H, Rafiq K, Mostofa M, / et al. Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury. J Pharmacol Sci, 2008,108(4):399-05 CrossRef
3. Guo C, Martinez-Vasquez D, Mendez GP, / et al. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology, 2006,147(11):5363-373 CrossRef
4. Nielsen FT, Jensen BL, Marcussen N, / et al. Inhibition of mineralocorticoid receptors with eplerenone alleviates short-term cyclosporin A nephrotoxicity in conscious rats. Nephrol Dial Transplant, 2008,23(9):2777-783 CrossRef
5. Lam EY, Funder JW, Nikolic-Paterson DJ, / et al. Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats. Endocrinology, 2006,147(7):3623-629. CrossRef
6. De las Heras N, Ruiz-Ortega M, Miana M, / et al. Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats. J Hypertens, 2007,25(3):629-38 CrossRef
7. Wolf G, Ziyadeh FN. Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron Physiol, 2007,106(2):26-1 CrossRef
8. Yoshida S, Nagase M, Shibata S, / et al. Podocyte injury induced by albumin overload / in vivo and / in vitro: involvement of TGF-beta and p38 MAPK. Nephron Exp Nephrol, 2008,108(3):e57-8 CrossRef
9. Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, / et al. Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int, 2002,62(3):901-13 CrossRef
10. Fujisawa G, Okada K, Muto S, / et al. Spironolactone prevents early renal injury in streptozotocininduced diabetic rats. Kidney Int, 2004,66(4):1493-502 CrossRef
11. Juknevicius I, Segal Y, Kren S, / et al. Effect of aldosterone on renal transforming growth factor-beta. Am J Physiol Renal Physiol, 2004,286(6):F1059-062 CrossRef
12. Kerjaschkj D, Neale TJ. Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis). J Am Soc Nephrol, 1996,7(12): 2518-52 - 作者单位：Zhan Fang (1) (2)
Chun Zhang (1)
Fangfang He (1)
Shan Chen (1)
Xifeng Sun (1)
Zhonghua Zhu (1)
Jianshe Liu (1)
Xianfang Meng (3)
1. Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
2. Department of Nephrology, Yantai Mountain Hospital, Yantai, 264000, China
3. Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
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