Identification of epigenetic modifications that contribute to pathogenesis in therapy-related AML: Effective integration of genome-wide histone modification with transcriptional profiles
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- 作者：Xinan (Holly) Yang ; Bin Wang ; John M Cunningham
- 关键词：computational biology ; t ; AML ; EZH2 ; H3K27me3 ; SEMA3A
- 刊名：BMC Medical Genomics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：2-supp
- 全文大小：4,725 KB
- 刊物主题：Human Genetics; Microarrays;
- 出版者：BioMed Central
- ISSN：1755-8794
文摘
Background Therapy-related, secondary acute myeloid leukemia (t-AML) is an increasingly frequent complication of intensive chemotherapy. This malignancy is often characterized by abnormalities of chromosome 7, including large deletions or chromosomal loss. A variety of studies suggest that decreased expression of the EZH2 gene located at 7q36.1 is critical in disease pathogenesis. This histone methyltransferase has been implicated in transcriptional repression through modifying histone H3 on lysine 27 (H3k27). However, the critical target genes of EZH2 and their regulatory roles remain unclear.