Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae

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• 作者：Xinchun Zheng ; Wencong Dai ; Xiaohui Chen ; Kunyuan Wang…
• 关键词：Caffeine ; Zebrafish ; Fatty liver ; ER stress ; Lipogenesis
• 刊名：Journal of Biomedical Science
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：22
• 期：1
• 全文大小：2,876 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish were unexplored. Thus, this study’s intentions are to establish a NAFLD model of zebrafish larvae and to examine the role of caffeine on fatty liver with the model.