Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer

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• 作者：Li Liu ; Yuchen Liu ; Chengle Zhuang ; Wen Xu ; Xing Fu ; Zhaojie Lv ; Hanwei Wu…
• 关键词：PCAT ; 1 ; Bladder cancer ; Proliferation ; Apoptosis
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：36
• 期：10
• 页码：7685-7689
• 全文大小：2,383 KB
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• 作者单位：Li Liu (1) (2)
  Yuchen Liu (1)
  Chengle Zhuang (1) (2)
  Wen Xu (3)
  Xing Fu (1)
  Zhaojie Lv (1)
  Hanwei Wu (1)
  Lisha Mou (1)
  Guoping Zhao (1) (4)
  Zhiming Cai (1) (2)
  Weiren Huang (1)
  
  1. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People鈥檚 Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
  2. Shantou University Medical College, Shantou, China
  3. State Key Laboratory Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
  4. Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play important roles in cancer development and progression. Prostate cancer-associated transcript 1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer. We hypothesized that PCAT-1 also have roles in bladder cancer. In this study, we found that PCAT-1 was up-regulated in bladder cancer compared to paired normal urothelium. Cell proliferation inhibition and apoptosis induction were also observed in PCAT-1 small hairpin RNA (shRNA)-transfected bladder cancer T24 and 5637 cells. Our data suggest that PCAT-1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer. Keywords PCAT-1 Bladder cancer Proliferation Apoptosis