Pharmacokinetic study of Gastrodia elata in rats
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- 作者：Chunlan Tang ; Li Wang ; Xinxin Liu ; Mengchun Cheng…
- 关键词：Gastrodia elata ; Parishin ; Pharmacokinetics ; Integrated pharmacokinetics
- 刊名：Analytical and Bioanalytical Chemistry
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：407
- 期：29
- 页码：8903-8910
- 全文大小：612 KB
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Li Wang (1)
Xinxin Liu (1)
Mengchun Cheng (1)
Hongbin Xiao (1) (3)
1. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, 116023, China
2. University of Chinese Academy of Science, Beijing, 100049, China
3. Beijing University of Chinese Medicine, Beijing, 100029, China - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Analytical Chemistry
Food Science
Inorganic Chemistry
Physical Chemistry
Monitoring, Environmental Analysis and Environmental Ecotoxicology - 出版者：Springer Berlin / Heidelberg
- ISSN：1618-2650
文摘
The pharmacokinetics of parishin, gastrodin, Gastrodia elata extract and Rhizoma Gastrodiae capsule was investigated by intragastric and/or intravenous administration to rats. Parishin was metabolized into nine metabolites after intravenous administration, and the area under the curve (AUC0–∞) of parishin and its metabolites (except parishin G and parishin E) increased nonlinearly from 72.5 to 220 mg/kg. When combining regression equation with the AUC0–∞ and dose of gastrodin injection, the percent conversion of parishin to gastrodin was obtained as 50 %. Based on multi-active metabolites of parishin in vivo, integrated pharmacokinetic mode was established. It is notable that each metabolite from parishin shares the similar metabolic process at three dosages of parishin and the bioavailability of parishin was approximately 14 %. The integrated pharmacokinetic mode was successfully applied to evaluate the holistic pharmacokinetics of gastrodin injection, G. elata extract and Rhizoma Gastrodiae capsule. The results showed that the holistic pharmacokinetics of gastrodin injection and G. elata extract was closed to that of gastrodin, but for parishin and Rhizoma Gastrodiae capsule, integrated pharmacokinetic parameters were more suitable to evaluate its holistic pharmacokinetics.