MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis

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• 作者：Xinyang Liu ; Zhichao Wang ; Xiaowei Zhang ; Jinjia Chang ; Wenbo Tang ; Lu Gan…
• 关键词：MUC1 ; Polymorphism ; Genetic ; Stomach neoplasms ; Meta ; analysis
• 刊名：SpringerPlus
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：3
• 期：1
• 全文大小：687KB
• 参考文献：Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Wang C, Wheeler W, Gail MH, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, et al.: A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet 2010,42(9):764鈥?67. doi:10.1038/ng.649 10.1038/ng.649CrossRef
  Blaser MJ: Linking Helicobacter pylori to gastric cancer. Nat Med 2000,6(4):376鈥?77. doi:10.1038/74627 10.1038/74627CrossRef
  Clark MF, Baudouin SV: A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med 2006,32(11):1706鈥?712. doi:10.1007/s00134鈥?06鈥?327-y 10.1007/s00134-006-0327-yCrossRef
  DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986,7(3):177鈥?88. 10.1016/0197-2456(86)90046-2CrossRef
  Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ (Clin Res Ed) 1997,315(7109):629鈥?34. 10.1136/bmj.315.7109.629CrossRef
  Gendler SJ: MUC1, the renaissance molecule. J Mammary Gland Biol Neoplasia 2001,6(3):339鈥?53. 10.1023/A:1011379725811CrossRef
  Ioannidis JP, Trikalinos TA: The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ 2007,176(8):1091鈥?096. doi:10.1503/cmaj.060410 10.1503/cmaj.060410CrossRef
  Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011,61(2):69鈥?0. doi:10.3322/caac.20107 10.3322/caac.20107CrossRef
  Jia Y, Persson C, Hou L, Zheng Z, Yeager M, Lissowska J, Chanock SJ, Chow WH, Ye W: A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. Cancer Causes Control 2010,21(2):313鈥?21. doi:10.1007/s10552鈥?09鈥?463鈥? 10.1007/s10552-009-9463-3CrossRef
  Kufe DW: Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer 2009,9(12):874鈥?85. doi:10.1038/nrc2761 10.1038/nrc2761CrossRef
  Li M, Huang L, Qiu H, Fu Q, Li W, Yu Q, Sun L, Zhang L, Hu G, Hu J, Yuan X: Helicobacter pylori Infection Synergizes with Three Inflammation-Related Genetic Variants in the GWASs to Increase Risk of Gastric Cancer in a Chinese Population. PLoS One 2013,8(9):e74976. doi:10.1371/journal.pone.0074976 10.1371/journal.pone.0074976CrossRef
  Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 2009,151(4):W65鈥?4.CrossRef
  Linden SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA: MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog 2009,5(10):e1000617. doi:10.1371/journal.ppat.1000617 10.1371/journal.ppat.1000617CrossRef
  Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959,22(4):719鈥?48.
  Ng W, Loh AX, Teixeira AS, Pereira SP, Swallow DM: Genetic regulation of MUC1 alternative splicing in human tissues. Br J Cancer 2008,99(6):978鈥?85. doi:10.1038/sj.bjc.6604617 10.1038/sj.bjc.6604617CrossRef
  Palmer AJ, Lochhead P, Hold GL, Rabkin CS, Chow WH, Lissowska J, Vaughan TL, Berry S, Gammon M, Risch H, El-Omar EM: Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations. Eur J Cancer Prev 2012,21(6):541鈥?44. doi:10.1097/CEJ.0b013e3283529b79 10.1097/CEJ.0b013e3283529b79CrossRef
  Saeki N, Saito A, Choi IJ, Matsuo K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee YS, Yoon KA, Kook MC, Park SR, Kim YW, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, Kato S, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, Katai H, Shimoda T, Yoshida T, Nakamura Y, et al.: A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology 2011,140(3):892鈥?02. doi:10.1053/j.gastro.2010.10.058 10.1053/j.gastro.2010.10.058CrossRef
  Schlesselman J: Case 鈥?Control Studies, Design, Conduct, Analysis. Oxford University Press, Oxford; 1982:220鈥?26.
  Skoog EC, Sjoling A, Navabi N, Holgersson J, Lundin SB, Linden SK: Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells. PLoS One 2012,7(5):e36378. doi:10.1371/journal.pone.0036378 10.1371/journal.pone.0036378CrossRef
  Song HR, Kim HN, Kweon SS, Choi JS, Shim HJ, Cho SH, Chung IJ, Park YK, Kim SH, Choi YD, Joo KW, Shin MH: Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population. Tumour Biol 2013. doi:10.1007/s13277鈥?13鈥?409鈥?
  Wu MS, Chen CJ, Lin JT: Host-environment interactions: their impact on progression from gastric inflammation to carcinogenesis and on development of new approaches to prevent and treat gastric cancer. Cancer Epidemiol Biomarkers Prev 2005,14(8):1878鈥?882. doi:10.1158/1055鈥?965.epi-04鈥?792 10.1158/1055-9965.EPI-04-0792CrossRef
  Xu Q, Yuan Y, Sun LP, Gong YH, Xu Y, Yu XW, Dong NN, Lin GD, Smith PN, Li RW: Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. Int J Oncol 2009,35(6):1313鈥?320.
  Yang XX, Li FX, Zhou CP, Hu NY, Wu YS, Li M: Association of Genetic Polymorphisms at 1q22 but not 10q23 with Gastric Cancer in a Southern Chinese Population. Asian Pac J Cancer Prev 2012,13(6):2519鈥?522. doi:10.7314/apjcp.2012.13.6.2519 10.7314/APJCP.2012.13.6.2519CrossRef
  Zhang HZ, Jin G, Li H, Ren C, Ding Y, Zhang Q, Deng B, Wang J, Hu Z, Xu Y, Shen H: Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population. Carcinogenesis 2011,32(6):848鈥?52. doi:10.1093/carcin/bgr051 10.1093/carcin/bgr051CrossRef
  Zheng L, Zhu C, Gu J, Xi P, Du J, Jin G: Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6,580 cases and 10,324 controls. Mol Biol Rep 2013. doi:10.1007/s11033鈥?13鈥?682鈥?
  
• 作者单位：Xinyang Liu (3)
  Zhichao Wang (4)
  Xiaowei Zhang (3)
  Jinjia Chang (3)
  Wenbo Tang (3)
  Lu Gan (3)
  Zheng Wu (3)
  Jin Li (3)
  
  3. Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China
  4. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

The association between MUC1 polymorphism rs4072037 and the risk of gastric cancer has been described in several studies. However, these studies yielded inconsistent results, especially in different pathological type of gastric cancer. Therefore, we performed this meta-analysis to evaluate the relationship between MUC1 gene polymorphism and gastric cancer susceptibility. A comprehensive database search was performed to identify eligible studies. Odds ratios with 95% confidence intervals were calculated to assess the strength of the association between MUC1 rs4072037 and risk of gastric cancer. Subgroup analyses, publication bias, and sensitivity analyses were also conducted. PubMed, EMBASE, Web of Science and CNKI databases were systematically searched to identify relevant studies. A total of 9 studies (12 datasets) were included in the meta-analysis including 10,410 cases and 11,437 controls. Overall, the G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR=0.70, 95% CI: 0.64鈥?.76). The association was significant in both anatomic location and pathological subtype subgroup analyses. However, the association was detected in Asian rather than Caucasian. Our findings demonstrate that the presence of the G allele at rs4072037 of the MUC1 gene may contribute to protection against gastric cancer in Asian. Further large studies of multiethnic groups are needed to validate these findings. Keywords MUC1 Polymorphism Genetic Stomach neoplasms Meta-analysis