Effects of Triterpenoid From Schisandra chinensis on Oxidative Stress in Alcohol-Induced Liver Injury in Rats

详细信息    查看全文

• 作者：Bin Li (1)
  Lijie Zhu (1)
  Ting Wu (1)
  Jiachen Zhang (1)
  Xinyao Jiao (1)
  Xiuying Liu (1)
  Yanqun Wang (1)
  Xianjun Meng (1)
  
  1. College of Food Science ; Shenyang Agricultural University ; 120 Dongling Road ; Shenyang ; 110866 ; People鈥檚 Republic of China
  
• 关键词：Triterpenoid ; Schisandra chinensis ; Oxidative stress ; Alcohol ; Microsome
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：71
• 期：2
• 页码：803-811
• 全文大小：1,631 KB
• 参考文献：1. Singal, A. K., & Charlton, M. R. (2012). Nutrition in alcoholic liver disease. / Clinics in Liver Disease, / 16(4), 805鈥?26. CrossRef
  2. Lelbach, W. K. (1966). Liver damage in chronic alcoholism. Results of a clinical, clinical-chemical and bioptic-histological study in 526 alcoholic patients during a low-calorie diet in an open drinking sanatorium. / Acta Hepato-splenologica, / 13(6), 321鈥?49.
  3. O鈥橲hea, R. S., Dasarathy, S., & McCullough, A. J. (2010). Alcoholic Liver Disease. / Hepatology, / 51(1), 307鈥?28. CrossRef
  4. Fan, J. G. (2013). Epidemiology of alcoholic and nonalcoholic fatty liver disease in China. / Journal of Gastroenterology and Hepatology, / 28(Suppl 1), 11鈥?7. CrossRef
  5. Daniluk, J., Szuster-Ciesielska, A., Drabko, J., & Kandefer-Szerszen, M. (2001). Serum cytokine levels in alcohol-related liver cirrhosis. / Alcohol, / 23(1), 29鈥?4. CrossRef
  6. Isayama, F., Froh, M., Bradford, B. U., McKim, S. E., Kadiiska, M. B., Connor, H. D., et al. (2003). The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice. / Free Radical Biology and Medicine, / 35(35), 12鈥?581.
  7. De Minicis, S., & Brenner, D. A. (2008). Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. / Journal of Gastroenterology and Hepatology, / 23(Suppl 1), S98鈥揝103. CrossRef
  8. Lindros, K. O. (1995). Alcoholic liver disease: pathobiological aspects. / Journal of Hepatology., / 23(Suppl 1), 7鈥?5.
  9. Balkan, J., Dogru-Abbasoglu, S., Kanbagli, O., Cevikbas, U., Aykac-Toker, G., & Uysal, M. (2001). Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress. / Human and Experimental Toxicology, / 20(5), 251鈥?54. CrossRef
  10. Cederbaum, A. I., Lu, Y., & Wu, D. (2009). Role of oxidative stress in alcohol-induced liver injury. / Archives of Toxicology, / 83(6), 519鈥?48. CrossRef
  11. Sharma, R. K., Pasqualotto, F. F., Nelson, D. R., Thomas, A. J, Jr, & Agarwal, A. (1999). The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. / Human Reproduction, / 14(11), 2801鈥?807. CrossRef
  12. Apel, K., & Hirt, H. (2004). Reactive oxygen species: metabolism, oxidative stress, and signal transduction. / Annual Review of Plant Biology, / 55, 373鈥?99. CrossRef
  13. Tang, Y., Gao, C., Xing, M., Li, Y., Zhu, L., Wang, D., et al. (2012). Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative damage. / Food and Chemical Toxicology, / 50(5), 1194鈥?200. CrossRef
  14. Wang, Y., Millonig, G., Nair, J., Patsenker, E., Stickel, F., Mueller, S., et al. (2009). Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. / Hepatology, / 50, 453鈥?61. CrossRef
  15. Lu, Y., & Cederbaum, A. I. (2008). CYP2E1 and oxidative liver injury by alcohol. / Free Radical Biology and Medicine, / 44, 723鈥?38. CrossRef
  16. Bilzer, M., & Gerbes, A. L. (2000). Preservation injury of the liver: mechanisms and novel therapeutic strategies. / Journal of Hepatology, / 32, 508鈥?15. CrossRef
  17. Jaeschke, H. (2011). Reactive oxygen and mechanisms of inflammatory liver injury: present concepts. / Journal of Gastroenterology and Hepatology, / 26(Suppl 1), 173鈥?79. CrossRef
  18. Stenger, C., Naves, T., Verdier, M., & Ratinaud, M. H. (2011). The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status. / International Journal of Oncology, / 39, 601鈥?09.
  19. Lu, Y., & Chen, D. F. (2009). Analysis of Schisandra chinensis and Schisandra sphenanthera. / Journal of Chromatography A, / 1216, 1980鈥?990. CrossRef
  20. Panossian, A., & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. / Journal of Ethnopharmacology, / 118, 183鈥?12. CrossRef
  21. Dilshara, M. G., Jayasooriya, R. G., Kang, C. H., Lee, S., Park, S. R., Jeong, J. W., et al. (2013). Downregulation of pro-inflammatory mediators by a water extract of Schisandra chinensis (Turcz.) Baill fruit in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. / Environmental Toxicology and Pharmacology, / 36, 256鈥?64. CrossRef
  22. Liu, G. T. (1989). Pharmacological actions and clinical use of fructus schizandrae. / Chinese Medical Journal, / 102, 740鈥?49.
  23. Guo, L. Y., Hung, T. M., Bae, K. H., Shin, E. M., Zhou, H. Y., Hong, Y. N., et al. (2008). Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. / European Journal of Pharmacology, / 591, 293鈥?99. CrossRef
  24. Szeto, Y. T., Wong, S. C., Wong, J. W., Kalle, W., & Pak, S. C. (2011). In vitro antioxidation activity and genoprotective effect of selected Chinese medicinal herbs. / American Journal of Chinese Medicine, / 39, 827鈥?38. CrossRef
  25. Kim, K. J., Yoon, K. Y., Hong, H. D., & Lee, B. Y. (2012). Schisandra chinensis prevents hepatic lipid peroxidation and oxidative stress in rats subjected to heat environmental stress. / Phytotherapy Research, / 26, 1674鈥?680. CrossRef
  26. Cheng, N., Ren, N., Gao, H., Lei, X., Zheng, J., & Cao, W. (2013). Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. / Food and Chemical Toxicology, / 55, 234鈥?40. CrossRef
  27. Park, H. J., Lee, S. J., Song, Y., Jang, S. H., Ko, Y. G., Kang, S. N., et al. (2014). Schisandra chinensis prevents alcohol-induced fatty liver disease in rats. / Journal of Medicinal Food, / 17, 103鈥?10. CrossRef
  28. Hwang, I. S., Kim, J. E., Lee, Y. J., Kwak, M. H., Choi, Y. H., Kang, B. C., et al. (2013). Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury. / International Journal of Molecular Medicine, / 31, 888鈥?98.
  29. Chiu, H. F., Chen, T. Y., Tzeng, Y. T., & Wang, C. K. (2013). Improvement of liver function in humans using a mixture of schisandra fruit extract and sesamin. / Phytotherapy Research, / 27, 368鈥?73. CrossRef
  30. Reddy, V. D., Padmavathi, P., Hymavathi, R., Maturu, P., & Varadacharyulu, N. (2014). Alcohol-induced oxidative stress in rat liver microsomes: protective effect of Emblica officinalis. / Pathophysiology, / 21, 153鈥?59. CrossRef
  31. Gao, B., & Bataller, R. (2011). Alcoholic liver disease: pathogenesis and new therapeutic targets. / Gastroenterology, / 141, 1572鈥?585. CrossRef
  32. Liu, C., Zhang, S., & Wu, H. (2009). Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract. / Natural Product Research, / 23, 1390鈥?401. CrossRef
  33. Liu, C. J., Zhang, S. Q., Zhang, J. S., Liang, Q., & Li, D. S. (2012). Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis (Turcz.) Baill. / Natural Product Research, / 26, 2199鈥?203. CrossRef
  34. Ozcan, M. E., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004). Antioxidant enzyme activities and oxidative stress in affective disorders. / International Clinical Psychopharmacology, / 19, 89鈥?5. CrossRef
  35. Popovic, M., Janicijevic-Hudomal, S., Kaurinovic, B., Rasic, J., & Trivic, S. (2008). Effects of various drugs on alcohol-induced oxidative stress in the liver. / Molecules, / 13, 2249鈥?259. CrossRef
  36. Su, T., Mao, C., Yin, F., Yu, Z., Lin, Y., Song, Y., et al. (2013). Effects of unprocessed versus vinegar-processed Schisandra chinensis on the activity and mRNA expression of CYP1A2, CYP2E1 and CYP3A4 enzymes in rats. / Journal of Ethnopharmacology, / 146, 734鈥?43. CrossRef
  37. Wang, B. L., Hu, J. P., Sheng, L., & Li, Y. (2011). Effects of Schisandra chinensis (Wuweizi) constituents on the activity of hepatic microsomal CYP450 isozymes in rats detected by using a cocktail probe substrates method. / Yao Xue Xue Bao, / 46, 922鈥?27.
  38. Choi, A. M., & Alam, J. (1996). Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. / American Journal of Respiratory Cell and Molecular Biology, / 15, 9鈥?9. CrossRef
  39. Morse, D., & Choi, A. M. (2002). Heme oxygenase-1: the 鈥渆merging molecule鈥?has arrived. / American Journal of Respiratory Cell and Molecular Biology, / 27, 8鈥?6. CrossRef
  40. Kim, H. P., Pae, H. O., Back, S. H., Chung, S. W., Woo, J. M., Son, Y., et al. (2011). Heme oxygenase-1 comes back to endoplasmic reticulum. / Biochemical and Biophysical Research Communications, / 404, 1鈥?. CrossRef
  41. Park, S. Y., Park da, J., Kim, Y. H., Kim, Y., Kim, S. G., Shon, K. J., et al. (2011). Upregulation of heme oxygenase-1 via PI3聽K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages. / Immunology Letters, / 139, 93鈥?01. CrossRef
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

Alcohol-induced oxidative stress plays a crucial role in the pathological development of alcoholic liver disease. The aim of this study was to investigate the effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats. We found that the administration of triterpenoid attenuated alcohol-induced oxidative stress in multiple organs including liver. Moreover, the impaired liver function and histological changes resulted from alcohol consumption was improved by triterpenoid treatment. Finally, we found that pretreatment with triterpenoid from Schisandra chinensis to alcohol-fed rats increased the expression level of haem oxygenase-1 (HO-1) while inhibited the induction of cytochrome P-450 2E1 (CYP2E1) in liver microsomes. Further assays revealed that the microsomal activity of HO-1 was accordingly induced whereas CYP2E1 was suppressed in rats received triterpenoid intervention. Our findings suggest that triterpenoid from Schisandra chinensis may protect against alcohol-induced liver injury through ameliorating oxidative stress in rats.