Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT
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- 作者：Xueling Ou ; Shaohui Cai ; Peng Liu ; Jun Zeng ; Yuwen He ; Xinyao Wu and Jun Du
- 关键词：Indoleamine ; pyrrole 2 ; 3 ; dioxygenase ; 1 ; methyl ; tryptophan ; Dendritic cells ; Cancer vaccines
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2008
- 出版时间：May, 2008
- 年：2008
- 卷：134
- 期：5
- 页码：525-533
- 全文大小：484.8 KB
文摘
Purpose Dendritic cell (DC)-based cancer vaccines are currently being evaluated as novel anti-tumor vaccination strategies, but in some cases, they are demonstrated to have poor clinical efficacies than anticipated. A potential reason is immune tolerance due to the immunosuppressive enzyme, indoleamine-pyrrole 2,3-dioxygenase (IDO). The aim of this study was to determine whether blocking the activity of IDO might improve the anti-tumor efficacy of DC/Lewis lung carcinoma (LLC) fusion vaccine applied to the mouse LLC model.