CXXC5 regulates differentiation of C2C12 myoblasts into myocytes
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- 作者：Guangming Li (1) (2)
Xiangli Ye (1)
Xiyang Peng (1)
Yun Deng (1)
Wuzhou Yuan (1)
Yongqing Li (1)
Xiaoyang Mo (1)
Xijun Wang (1)
Yongqi Wan (1)
Xianchu Liu (1)
Tingfang Chen (1)
Zhigang Jiang (1)
Xiongwei Fan (1)
Xiushan Wu (1)
Yuequn Wang (1) - 关键词：C2C12 ; Skeletal myogenesis ; Myotube ; Luciferase reporters ; Differentiation
- 刊名：Journal of Muscle Research and Cell Motility
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：35
- 期：5-6
- 页码：259-265
- 全文大小：501 KB
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Xiangli Ye (1)
Xiyang Peng (1)
Yun Deng (1)
Wuzhou Yuan (1)
Yongqing Li (1)
Xiaoyang Mo (1)
Xijun Wang (1)
Yongqi Wan (1)
Xianchu Liu (1)
Tingfang Chen (1)
Zhigang Jiang (1)
Xiongwei Fan (1)
Xiushan Wu (1)
Yuequn Wang (1)
1. The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China
2. College of Life Sciences, Hunan University of Science and Technology, Xiangtan, 410121, Hunan, China - ISSN：1573-2657
文摘
CXXC5 is a member of the CXXC-type zinc-finger domain containing protein family, which is suggested to function in gene transcription, cell adhesion and cytoskeleton organization. Previous studies have revealed that CXXC5 is expressed in skeletal muscle, but whether it regulates skeletal myogenesis is yet unknown. Here, we screened for the possible signaling pathways in which CXXC5 might participate using luciferase gene reporters. The results indicated that CXXC5 significantly increased the activities of the promoters of genes involved in skeletal muscle differentiation. We therefore studied the role of CXXC5 during skeletal myogenesis in C2C12 myoblasts. Our findings suggest that overexpression of CXXC5 in C2C12 myoblasts facilitated myocyte differentiation, while RNAi interference of CXXC5 significantly inhibited the differentiation of C2C12 myoblasts. This study suggests that CXXC5 plays a significant role in regulating skeletal myogenesis.