Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
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- 作者：Yang Cai ; Hong Kong ; Yin-Bing Pan ; Lai Jiang ; Xiu-Xiu Pan…
- 关键词：Morphine tolerance ; Procyanidins ; NLRP3 inflammasome ; Interleukin ; 1β ; Microglia
- 刊名：Journal of Neuroinflammation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：1,861 KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
文摘
Background The development of antinociceptive tolerance following repetitive administration of opioid analgesics significantly hinders their clinical use. Evidence has accumulated indicating that microglia within the spinal cord plays a critical role in morphine tolerance. The inhibitor of microglia is effective to attenuate the tolerance; however, the mechanism is not fully understood. Our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on NOD-like receptor protein3 (NLRP3) inflammasome in microglia.