Chemical constituents from Inula wissmanniana and their anti-inflammatory activities

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• 作者：Chunhui Wang (1)
  Xufeng Zhang (1)
  Panlei Wei (1)
  Xiangrong Cheng (1)
  Jie Ren (1)
  Shikai Yan (1)
  Weidong Zhang (1) (2)
  Huizi Jin (1)
  
• 关键词：Inula wissmanniana ; Inositol derivatives ; Flavonolignans ; Thymol derivatives ; Anti ; inflammatory
• 刊名：Archives of Pharmacal Research
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：36
• 期：12
• 页码：1516-1524
• 全文大小：
• 作者单位：Chunhui Wang (1)
  Xufeng Zhang (1)
  Panlei Wei (1)
  Xiangrong Cheng (1)
  Jie Ren (1)
  Shikai Yan (1)
  Weidong Zhang (1) (2)
  Huizi Jin (1)
  
  1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People’s Republic of China
  2. School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China
  
• ISSN：1976-3786

文摘

Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), one new flavonolignan 23-o-acetylsilychristin A (3), and one new thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds, including ten flavonolignans (5–14) and three thymol derivatives (15–17) were isolated from the aerial part of Inula wissmanniana. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The anti-inflammatory activities of the compounds were tested against LPS-induced NO production in RAW 264.7 macrophages.