Progesteron zur Pr盲vention der Fr眉hgeburt

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• 作者：Dr. A. Nonnenmacher (1)
  
• 关键词：Perinatale Mortalit盲t ; 17 ; 伪 ; Hydroxyprogesteron ; Zervixverk眉rzung ; Cerclage ; Prostaglandine ; Perinatal mortality ; 17 ; 伪 hydroxyprogesterone ; Shortened cervical canal ; Preterm labor ; Prostaglandines
• 刊名：Der Gyn?kologe
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：45
• 期：7
• 页码：533-537
• 全文大小：319KB
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• 作者单位：Dr. A. Nonnenmacher (1)
  
  1. Kliniken f眉r Geburtsmedizin, Campus Virchow Klinikum, Charit茅 Universit盲tsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
  

文摘

The rate of preterm delivery in Germany has remained constant for many years and there is currently no satisfactory solution particularly for spontaneous preterm labor. In recent years progesterone has become a focus of attention for prevention of preterm birth. At the moment there are two medications which can be used: 17-伪 hydroxyprogesterone caproat and progesterone whereby 17-伪 hydroxyprogesterone caproat can be used in pregnant women with a history of preterm labor. In 2011 the U.S. Food and Drug Administration (FDA) approved this application. Progesterone is given to women with a history of preterm labor or with an asymptomatic short cervix but there seems to be no positive effect for women with multiple gestations. There is also no effect on preterm rupture of membranes, cerclage or positive fibronectin test. At present there is evidence indicating that progesterone can be given for prevention of preterm labor in women with a history of preterm labor or a shortened cervix and a single gestation. Whether the use of progesterone will decrease the rate of spontaneous preterm labor in the coming years still has to be proven.