CA1 contributes to microcalcification and tumourigenesis in breast cancer

详细信息    查看全文

• 作者：Yabing Zheng ; Bing Xu ; Yan Zhao ; He Gu ; Chang Li ; Yao Wang ; Xiaotian Chang
• 关键词：Breast cancer ; Microcalcification ; Tumourigenesis ; Carbonic anhydrase I (CA1) ; Androgen receptor (AR) ; X ; box binding protein 1 (XBP1)
• 刊名：BMC Cancer
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：3,988 KB
• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background Although mammary microcalcification is frequently observed and has been associated with poor survival in patients with breast cancer, the genesis of calcification remains unclear. Carbonic anhydrase I (CA1) has been shown to promote calcification by catalysing the hydration of CO₂. This study aimed to determine whether CA1 was correlated with microcalcification and with other processes that are involved in breast cancer tumourigenesis.