Systemic and renal growth hormone–IGF1 axis involvement in a mouse model of type 2 diabetes

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• 作者：Y. Segev ; R. Eshet ; O. Yakir ; N. Haim ; M. Phillip and D. Landau
• 关键词：db/db mouse ; Diabetic nephropathy ; Forkhead transcription factors ; Glomerular volume ; Growth hormone receptor ; IGFBP1 ; Somatostatin ; Type 2 diabetes
• 刊名：Diabetologia
• 出版年：2007
• 出版时间：June, 2007
• 年：2007
• 卷：50
• 期：6
• 页码：1327-1334
• 全文大小：229 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis In previous studies we have shown a significant involvement of the growth hormone (GH)–IGF axis in animal models of type 1 diabetes mellitus, but the role of this endocrine system in type 2 diabetes mellitus is less well characterised. We therefore examined the endocrine and renal GH–IGF axis changes in db/db mice, a model of type 2 diabetes mellitus and nephropathy.