Morphological alterations in the liver of yellow perch (Perca flavescens) from a biological mercury hotspot
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- 作者：Anne-Katrin Müller ; Markus Brinkmann…
- 关键词：Methyl mercury ; Yellow perch ; Macrophage aggregates ; Ultrastructure
- 刊名：Environmental Science and Pollution Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：22
- 期：22
- 页码：17330-17342
- 全文大小：3,020 KB
- 参考文献：Agius C, Roberts RJ (1981) Effects of starvation on the melano-macrophage centres of fish. J Fish Biol 19:161-69. doi:10.-111/?j.-095-8649.-981.?tb05820.?x CrossRef
Agius C, Roberts RJ (2003) Melano-macrophage centres and their role in fish pathology. J Fish Dis 26:499-09. doi:10.-046/?j.-365-2761.-003.-0485.?x CrossRef
Baatrup E, Danscher G (1987) Cytochemical demonstration of mercury deposits in trout liver and kidney following methyl mercury intoxication: differentiation of two mercury pools by selenium. Ecotoxicol Environ Saf 14(2):129-41. doi:10.-016/-147-6513(87)90055-8 CrossRef
Barghigiani C, Pellegrinis D, Carpene E (1989) Mercury binding proteins in liver and muscle of flat fish from the northern Tyrrhenian sea. Comp Biochem Physiol C: Comp Pharmacol 94(1):309-12. doi:10.-016/-742-8413(89)90184-9 CrossRef
Barst BD, Gevertz AK, Chumchal MM, Smith JD, Rainwater TR, Drevnick PE, Hudelson KE, Hart A, Verbeck GF, Roberts AP (2011) Laser ablation ICP-MS co-localization of mercury and immune response in fish. Environ Sci Technol 45(20):8982-988. doi:10.-021/?es201641x CrossRef
Batchelar K (2011) Effects of mercury on the general and reproductive health of yellow perch in Kejimkujik National Park, Nova Scotia. Msc. thesis, University of New Brunswick
Batchelar KL, Kidd KA, Drevnick PE, Munkittrick KR, Burgess NM, Roberts AP, Smith JD (2013) Evidence of impaired health in yellow perch (Perca flavescens) from a biological mercury hotspot in northeastern north America. Environ Toxicol Chem 32(3):627-37. doi:10.-002/?etc.-099 CrossRef
Beckvar N, Dillon TM, Read LB (2005) Approaches for linking whole-body fish tissue residues of mercury or DDT to biological effects thresholds. Environ Toxicol Chem 24(8):2094-105. doi:10.-897/-4-284R.- CrossRef
Blazer VS, Wolke RE, Brown J, Powell CA (1987) Piscine macrophage aggregate parameters as health monitors: effect of age, sex, relative weight, season and site quality in largemouth bass (Micropterus salmoides). Aquat Toxicol 10(4):199-15. doi:10.-016/-166-445X(87)90012-9 CrossRef
Bloom NS (1992) On the chemical form of mercury in edible fish and marine invertebrate tissue. Can J Fish Aquat Sci 49(5):1010-017. doi:10.-139/?f92-113 CrossRef
Brown CL, George CJ (1985) Age-dependent accumulation of macrophage aggregates in the yellow perch, Perca flavescens (Mitchill). J Fish Dis 8:135-38. doi:10.-111/?j.-365-2761.-985.?tb01195.?x CrossRef
Brown TG, Runciman B, Bradford MJ, Pollard S (2009) A biological synopsis of yellow perch (Perca flavescens). Can Manuscr Rep Fish Aquat Sci 2883:v + 28 p
Cizdziel J, Hinners T, Cross C, Pollard J (2003) Distribution of mercury in the tissues of five species of freshwater fish from Lake Mead, USA. J Environ Monitor 5(5):802. doi:10.-039/?b307641p CrossRef
Dinno A (2014) dunn.test: Dunn’s test of multiple comparisons using rank sums. R package version 1.2.0 http://?CRAN.?R-project.?org/?package=?dunn.?test , Accessed 12 Oct 2014
Dittman JA, Driscoll CT (2009) Factors influencing changes in mercury concentrations in lake water and yellow perch (Perca flavescens) in Adirondack lakes. Biogeochemistry 93(3):179-96. doi:10.-007/?s10533-009-9289-9 CrossRef
Drevnick PE, Roberts AP, Otter RR, Hammerschmidt CR, Klaper R, Oris JT (2008) Mercury toxicity in livers of northern pike (Esox lucius) from Isle Royale, USA. Comp Biochem Physiol C: Toxicol Pharmacol 147(3):331-38. doi:10.-016/?j.?cbpc.-007.-2.-03
Durnford D, Dastoor A, Figueras-Nieto D, Ryjkov A (2010) Long range transport of mercury to the Arctic and across Canada. Atmos Chem Phys 10:6063-086. doi:10.-194/?acp-10-6063-2010 CrossRef
Evers DC, Kaplan JD, Meyer MW, Reaman PS, Braselton WE, Major A, Burgess N, Scheuhammer AM (1998) Geographic trend in mercury measured in common loon feathers and blood. Environ Toxicol Chem 17(2):173-83. doi:10.-002/?etc.-620170206 CrossRef
Evers DC, Han YJ, Driscoll CT, Kamman NC, Goodale MW, Fallon Lambert K, Holsen TM, Chen CY, Clair TA, Butler T (2007) Biological mercury hotspots in the Northeastern United States and Southeastern Canada. Bioscience 57(1):29-3. doi:10.-641/?B570107 CrossRef
Fishelson L (2006) Cytomorphological alterations of the thymus, spleen, head-kidney, and liver in cardinal fish (Apogonidae, Teleostei) as bioindicators of stress. J Morphol 267(1):57-9. doi:10.-002/?jmor.-0385 CrossRef
Fournie JW, Summers JK, Courtney LA, Engle VD (2001) Utility of splenic macrophage aggregates as an indicator of fish exposure to degraded environments. J Aquat Anim Health 13(2):105-16. doi:10.-577/-548-8667(2001)013<0105:?UOSMAA>2.-.?CO;2 CrossRef
Friedmann AS, Watzin MC, Brinck-Johnsen T, Leiter JC (1996) Low levels of dietary methylmercury inhibit growth and gonadal development in juvenile walleye (Stizostedion vitreum). Aquat Toxicol 35(3-):265-78. doi:10.-016/-166-445X(96)00796-5 CrossRef
Giari L, Simoni - 作者单位：Anne-Katrin Müller (1)
Markus Brinkmann (1)
Lisa Baumann (2)
Michael H. Stoffel (3)
Helmut Segner (2)
Karen A. Kidd (4)
Henner Hollert (1) (5) (6) (7)
1. Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany
2. Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, L?nggassstr. 122, 3012, Bern, Switzerland
3. Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, L?nggassstr. 120, 3012, Bern, Switzerland
4. Canadian Rivers Institute and Biology Department, University of New Brunswick, 100 Tucker Park Road, Saint John, New Brunswick, E2L 4L5, Canada
5. College of Resources and Environmental Science, Chongqing University, 1 Tiansheng Road Beibei, Chongqing, 400715, China
6. College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, 1239 Siping Road, Shanghai, China
7. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China - 刊物类别：Earth and Environmental Science
- 刊物主题：Environment
Environment
Atmospheric Protection, Air Quality Control and Air Pollution
Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
Industrial Pollution Prevention - 出版者：Springer Berlin / Heidelberg
- ISSN：1614-7499
文摘
Mercury (Hg) contamination is a global issue due to its anthropogenic release, long-range transport, and deposition in remote areas. In Kejimkujik National Park and National Historic Site, Nova Scotia, Canada, high concentrations of total mercury (THg) were found in tissues of yellow perch (Perca flavescens). The aim of this study was to evaluate a possible relationship between THg concentrations and the morphology of perch liver as a main site of metal storage and toxicity. Yellow perch were sampled from five lakes known to contain fish representing a wide range in Hg concentrations in fall 2013. The ultrastructure of hepatocytes and the distribution of Hg within the liver parenchyma were analyzed by transmission electron microscopy (TEM) and electron energy loss spectrometry (EELS). The relative area of macrophage aggregates (MAs) in the liver was determined using image analysis software and fluorescence microscopy. No relation between general health indicators (Fulton’s condition index) and THg was observed. In line with this, TEM examination of the liver ultrastructure revealed no prominent pathologies related to THg accumulation. However, a morphological parameter that appeared to increase with muscle THg was the relative area of MAs in the liver. The hepatic lysosomes appeared to be enlarged in samples with the highest THg concentrations. Interestingly, EELS analysis revealed that the MAs and hepatic lysosomes contained Hg. Keywords Methyl mercury Yellow perch Macrophage aggregates Ultrastructure