Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

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• 作者：Yun Kyoung Kim ; Mi Yeong Hwang ; Young Jin Kim ; Sanghoon Moon…
• 关键词：Genome ; wide association study ; Lipids ; Cardio ; metabolic traits ; Pleiotropy ; 12q24.12
• 刊名：Cardiovascular Diabetology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：1,153 KB
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• 作者单位：Yun Kyoung Kim (1)
  Mi Yeong Hwang (1)
  Young Jin Kim (1)
  Sanghoon Moon (1)
  Sohee Han (1)
  Bong-Jo Kim (1)
  
  1. Division of Structural and Functional Genomics, Center for Genome Sciences, National Institute of Health, Centers for Disease Control and Prevention, Cheongju-si, Chungcheongbuk-do, 28159, South Korea
  
• 刊物主题：Diabetes; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1475-2840

文摘

Background The genetic contribution to complex diseases or traits, including cardio-metabolic traits, has been elucidated recently by large-scale genome-wide association studies. These genome-wide association studies have indicated that most pleiotropic loci contain genes associated with lipids. Clinically, lipid related abnormalities are strongly associated with other diseases such as type 2 diabetes, coronary artery disease and hypertension. The aim of this study was to evaluate the shared genetic background of lipids and other cardio-metabolic traits.