MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix
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- 作者：Heejeong Lee (1)
Kyu Rae Kim (2)
Nam Hoon Cho (3)
Sung Ran Hong (4)
Hoiseon Jeong (4)
Sun Young Kwon (5)
Kwang Hwa Park (6)
Hee Jung An (7)
Tae Heon Kim (7)
Insun Kim (8)
Hye Kyoung Yoon (9)
Kwang Sun Suh (10)
Ki Ouk Min (1)
Hyun Joo Choi (1)
Ji Young Park (11)
Chong Woo Yoo (12)
Youn Soo Lee (1)
Hee Jin Lee (13)
Weon Sun Lee (13)
Chul Soo Park (14)
Yonghee Lee (15)
The Gynecological Pathology Study Group of the Korean Society of Pathologists
1. Department of Hospital Pathology ; College of Medicine ; The Catholic University of Korea ; 222 Banpo-daero ; Seocho-gu ; Seoul ; 137-701 ; Korea
2. Department of Pathology ; Asan Medical Center ; University of Ulsan College of Medicine ; 388-1 ; Pungnap 2-dong ; Songpa-gu ; Seoul ; 138-736 ; Korea
3. Department of Pathology ; Yonsei University College of Medicine ; 50-1 ; Yonse-ro ; Seodaemun-gu ; Seoul ; 120-752 ; Korea
4. Department of Pathology ; Cheil General Hospital and Women鈥檚 Healthcare Center ; Kwandong University College of Medicine ; 1-19 ; Mukjeong-dong ; Jung-gu ; Seoul ; 100-380 ; Korea
5. Department of Pathology ; Keimyung University College of Medicine ; 56 ; Dalseong-ro ; Jung-gu ; Daegu ; 700-712 ; Korea
6. Department of Pathology ; Yonsei University College of Medicine ; 20 ; Ilsan-ro ; Wonju ; Kangwon-do ; 220-701 ; Korea
7. Department of Pathology ; CHA University College of Medicine ; 59 ; Yatap-ro ; Bundang-gu ; Seongnam ; Gyeonggi-do ; 463-712 ; Korea
8. Department of Pathology ; Korea University College of Medicine ; 73 ; Inchon-ro ; Seongbuk-gu ; Seoul ; 136-705 ; Korea
9. Department of Pathology ; Inje University College of Medicine ; 75 ; Bokji-ro ; Jin-gu ; Busan ; 614-735 ; Korea
10. Department of Pathology ; Chungnam University College of Medicine ; 282 ; Munhwa-ro ; Jung-gu ; Daejeon ; 301-721 ; Korea
11. Department of Pathology ; Kyungpook National University School of Medicine ; 130 ; Dongdeok-ro ; Jung-gu ; Daegu ; 700-721 ; Korea
12. Department of Pathology ; Center for Uterine Cancer ; Research Institute and Hospital ; National Cancer Center ; 323 ; Ilsan-ro ; Ilsandong-gu ; Goyang ; Gyeonggi-do ; 410-769 ; Korea
13. Department of Clinical Medicine Research Institute ; The Catholic University of Korea ; Bucheon St. Mary鈥檚 Hospital ; 327 ; Sosa-ro ; Wonmi-gu ; Bucheon ; Gyeonggi-do ; 420-717 ; Korea
14. Department of Internal Medicine ; College of Medicine ; The Catholic University of Korea ; 222 ; Banpo-daero ; Seocho-gu ; Seoul ; 137-701 ; Korea
15. Department of Pathology ; Ajou University College of Medicine ; 164 ; World Cup-ro ; Yeongtong-gu ; Suwon ; Gyeonggi-do ; 443-380 ; Korea - 关键词：microRNA ; Minimal deviation adenocarcinoma ; Notch ; Uterine cervix
- 刊名：World Journal of Surgical Oncology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：12
- 期：1
- 全文大小：1,730 KB
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- 出版者：BioMed Central
- ISSN：1477-7819
文摘
Background MicroRNA (miRNA) expression is known to be deregulated in cervical carcinomas. However, no data is available about the miRNA expression pattern for the minimal deviation adenocarcinoma (MDA) of uterine cervix. We sought to detect deregulated miRNAs in MDA in an attempt to find the most dependable miRNA or their combinations to understand their tumorigenesis pathway and to identify diagnostic or prognostic biomarkers. We also investigated the association between those miRNAs and their target genes, especially Notch1 and Notch2. Methods We evaluated miRNA expression profiles via miRNA microarray and validated them using.real-time PCR assays with 24 formalin-fixed, paraffin-embedded tissue blocks of MDA and 11 normal proliferative endocervical tissues as control. Expression for Notch1 and 2 was assessed by immunohistochemistry. Results MiRNA-135a-3p, 192-5p, 194-5p, and 494 were up-regulated, whereas miR-34b-5p, 204-5p, 299-5p, 424-5p, and 136-3p were down-regulated in MDA compared with normal proliferative endocervical tissues (all P P P P =0.036). Conclusions MDA showed distinctive expression profiles of miRNAs, Notch1, and Notch2 from normal proliferative endocervical tissues. In particular, miR-34b-5p and 194-5p might be used as diagnostic biomarkers and miR-494 as a prognostic predictor for MDA. The miR-34b-5p/Notch1 pathway as well as Notch2 might be important oncogenic contributors to MDA.