Post-ischemic Intravenous Administration of Allogeneic Dental Pulp-Derived Neurosphere Cells Ameliorated Outcomes of Severe Forebrain Ischemia in Rats
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- 作者：Airi Kumasaka ; Kaoru Kanazawa ; Hanako Ohke ; Ikumi Miura…
- 关键词：Global cerebral ischemia ; Dental pulp ; Neurosphere ; Dental pulp stem cells ; Rat
- 刊名：Neurocritical Care
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：26
- 期：1
- 页码：133-142
- 全文大小：
- 刊物主题：Internal Medicine; Neurology; Intensive / Critical Care Medicine;
- 出版者：Springer US
- ISSN：1556-0961
- 卷排序：26
文摘
BackgroundTransplantation of bone marrow or adipose-derived mesenchymal stem cells (MSCs) for various neurological disorders has yielded promising results in models of focal cerebral ischemia. Dental pulp stem cells (DPSCs) are a type of MSC. In serum-free culture, they can form neurospheres that contain nestin-positive neuronal progenitor cells. We hypothesized that transplantation of dental pulp-derived neurosphere cells would ameliorate outcomes of global cerebral ischemia, the pathophysiology of which is known to resist conventional treatments.We also hypothesized that transplantation of dental pulp-derived cells would provide some neuroprotection in this pathology due to the presence of DPSCs.