Simultaneous quantification of several classes of antibiotics in water, sediments, and fish muscles by liquid chromatography-tandem mass spectrometry

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• 作者：Yimei Wei (1) (2)
  Yuan Zhang (2)
  Jian Xu (2)
  Changsheng Guo (2)
  Lei Li (2)
  Wenhong Fan (3)
  
• 关键词：antibiotics ; liquid chromatography ; tandem mass spectrometry (LC ; MS/MS) ; water ; sediment ; fish muscle
• 刊名：Frontiers of Environmental Science & Engineering
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：8
• 期：3
• 页码：357-371
• 全文大小：
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• 作者单位：Yimei Wei (1) (2)
  Yuan Zhang (2)
  Jian Xu (2)
  Changsheng Guo (2)
  Lei Li (2)
  Wenhong Fan (3)
  
  1. College of Environment, Liaoning University, Shenyang, 110036, China
  2. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China
  3. Department of Environmental Science and Engineering, School of Chemistry and Environment, Beihang University, Beijing, 100191, China
  
• ISSN：2095-221X

文摘

Precise and sensitive methods for the simultaneous determination of different classes of antibiotics, including sulphonamides, fluoroquinolones, macrolides, tetracyclines, and trimethoprim in surface water, sediments, and fish muscles were developed. In water samples, drugs were extracted with solid-phase extraction (SPE) by passing 1000 mL of water through hydrophilic lipophilic balanced (HLB) SPE cartridges. Sediment samples were solvent-extracted, followed by tandem SPE (strong anion exchange (SAX) + HLB) clean-ups. Fish muscles were extracted by a mixture of acetonitrile and citric buffer (80:20, v/v) solution, and cleaned by SPE. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) with multiple reaction monitoring (MRM) detection was employed to quantify all compounds. The recoveries for the antibiotics in the spiked water, sediment, and fish samples were 60.2%-5.8%, 48.1%-05.3%, and 59.8%-03.4%, respectively. The methods were applied to samples taken from Dianchi Lake, China. It showed that concentrations of the detected antibiotics ranged from limits of quantification (LOQ) to 713.6 ng·L? (ofloxacin) in surface water and from less than LOQ to 344.8 μg·kg? (sulphamethoxazole) in sediments. The number of detected antibiotics and the overall antibiotic concentrations were higher in the urban area than the rural area, indicating the probable role of livestock and human activities as important sources of antibiotic contamination. In fish muscles, the concentration of norfloxacin was the highest (up to 38.5 μg·kg?), but tetracyclines and macrolides were relatively low. Results showed that the methods were rapid and sensitive, and capable of determining several classes of antibiotics from each of the water, sediment, and fish matrices in a single run.