AKT and JNK Signaling Pathways Increase the Metastatic Potential of Colorectal Cancer Cells by Altering Transgelin Expression

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• 作者：Huimin Zhou ; Yiming Zhang ; Qikui Chen ; Ying Lin
• 关键词：Transgelin ; SM22 ; AKT ; JNK ; Metastasis ; Colorectal cancer
• 刊名：Digestive Diseases and Sciences
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：61
• 期：4
• 页码：1091-1097
• 全文大小：2,538 KB
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• 作者单位：Huimin Zhou (1)
  Yiming Zhang (2)
  Qikui Chen (1)
  Ying Lin (1)
  
  1. Department of Gastroenterology, The Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107. W. Yanjiang Road, Guangzhou, 510120, People’s Republic of China
  2. Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Background Transgelin (SM22) plays a crucial role in colorectal cancer (CRC) progression; nevertheless, its upstream regulatory mechanisms are poorly defined. AKT and JNK signaling pathways are strongly associated with tumor progression and metastasis, and there are some indications that these pathways might be involved in transgelin regulation.