Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin

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• 作者：Xin Lv ; Dong-mei Song ; Ying-hao Niu ; Bao-shan Wang
• 关键词：Cisplatin ; Hep ; 2 ; HO ; 1 ; Nrf ; 2 ; Apoptosis
• 刊名：Apoptosis
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：21
• 期：4
• 页码：489-501
• 全文大小：3,008 KB
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• 作者单位：Xin Lv (1)
  Dong-mei Song (1)
  Ying-hao Niu (1)
  Bao-shan Wang (1) (2)
  
  1. Department of Otolaryngology and Allergy, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, People’s Republic of China
  2. Hebei Medical University, No. 361, Zhongshan East Road, Shijiazhuang, 050017, Hebei, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Cell Biology
  Biochemistry
  Virology
  
• 出版者：Springer Netherlands
• ISSN：1573-675X

文摘

It has been previously reported that cisplatin is a well-known anticancer drug being used against a wide range of malignancies including head and neck, ovarian and non-small cell lung carcinoma, and demonstrated its anticancer activity by reacting with DNA or changing cell structure, immune response, reactive oxygen species level (ROS). In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation. The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin. Furthermore, the HO-1 expression induced by cisplatin was strongly inhibited by the knockdown of nuclear factor-erythroid-2-related factor-2 (Nrf-2), and the oxidative damages induced by cisplatin were significantly enhanced. Therefore, it may be concluded that the inhibition of HO-1 or the knockdown of Nrf-2 significantly enhanced cisplatin’s anticancer effects on Hep-2 cells. In clinic, with the overexpression of HO-1 in laryngeal squamous cancer tissues, the combination of cisplatin with the inhibitor of HO-1 or Nrf-2 siRNA may act as a new method to the treatment of laryngeal squamous cancer.