Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid
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- 作者：Yuxin Ma ; Chang Zhou ; Guoying Li ; Yinghong Tian ; Jing Liu ; Li Yan…
- 关键词：Neuropathic pain ; Cognitive deficit ; Kainic acid ; Marginal division ; Spinal cord
- 刊名：Neurochemical Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：40
- 期：11
- 页码：2357-2364
- 全文大小：3,299 KB
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Chang Zhou (1)
Guoying Li (1)
Yinghong Tian (2)
Jing Liu (1)
Li Yan (1)
Yuyun Jiang (1)
Sumin Tian (3)
1. Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China
2. Department of Physiology, Southern Medical University, Guangzhou, People’s Republic of China
3. Department of Physiology, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Neurosciences
Biochemistry
Neurology - 出版者：Springer Netherlands
- ISSN：1573-6903
文摘
Neuropathic pain and cognitive deficit are frequently comorbidity in clinical, but their underlying correlation and mechanisms remain unclear. Here, we utilized a combined rat model including kainic acid (KA) injection into bilateral striatal marginal division and chronic constriction nerve injury (CCI). PET/CT scans revealed that the SUVmax of KA rats was significantly decreased when compared to naive and saline rats. In contrast to the naive and saline rats, KA rats had longer latencies in locating the hidden platform on day 4, 5 in Morris water maze task. Thermal hyperalgesia and mechanical allodynia of KA rats were alleviated following CCI. Immunostaining results showed that substance P was markedly increased within ipsilateral spinal cord dorsal horn of KA rats after CCI, especially on the post-operative day 14. By means of real-time PCR, the up-regulation of GluR within ipsilateral spinal cord dorsal horn was observed in all KA and CCI rats. PKCγ, IL-6 and NF-κB were up-regulated in both CCI rats when compared to naive and their respective sham rats. These results suggest that cognitive impairment of rats altered the pain behaviors, and these intracellular regulators play crucial roles in the process of neuropathic pain.