Assessing liver function in patients with HBV-related HCC: a comparison of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI

详细信息    查看全文

• 作者：Ying Ding ; Sheng-Xiang Rao ; Caizhong Chen ; Renchen Li ; Meng-Su Zeng
• 关键词：Gd ; EOB ; DTPA ; T 1 relaxation time ; Magnetic resonance imaging ; Diffusion ; weighted imaging ; Liver function
• 刊名：European Radiology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：25
• 期：5
• 页码：1392-1398
• 全文大小：1,687 KB
• 参考文献：1. Zipprich, A, Kuss, O, Rogowski, S (2010) Incorporating indocyanin green clearance into the Model for End Stage Liver Disease (MELD-ICG) improves prognostic accuracy in intermediate to advanced cirrhosis. Gut 59: pp. 963-968 CrossRef
  2. Zappa, M, Dondero, F, Sibert, A, Vullierme, MP, Belqhiti, J, Vilqrain, V (2009) Liver regeneration at day 7 after right hepatectomy: global and segmental volumetric analysis by using CT. Radiology 252: pp. 426-432
  3. Stauber, RE, Wagner, D, Stadlbauer, V (2009) Evaluation of indocyanine green clearance and model for end-stage liver disease for estimation of short-term prognosis in decompensated cirrhosis. Liver Int 29: pp. 1516-1520 CrossRef
  4. Cucchetti, A, Ercolani, G, Vivarelli, M (2006) Impact of model for end-stage liver disease (MELD) score on prognosis after hepatectomy for hepatocellular carcinoma on cirrhosis. Liver Transpl 12: pp. 966-971 CrossRef
  5. Kamath, PS, Kim, WR (2007) The model for end-stage liver disease (MELD). Hepatology 45: pp. 797-805 CrossRef
  6. Tam, HH, Collins, DJ, Wallace, T, Brown, G, Riddell, A, Koh, DM (2012) Segmental liver hyperintensity in malignant biliary obstruction on diffusion weighted MRI: associated MRI findings and relationship with serum alanine aminotransferase levels. Br J Radiol 85: pp. 22-28 CrossRef
  7. Watanabe, H, Kanematsu, M, Goshima, S (2011) Staging hepatic fibrosis: comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging—preliminary observations. Radiology 259: pp. 142-150 CrossRef
  8. Verloh, N, Haimerl, M, Zeman, F (2014) Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla. Eur Radiol 24: pp. 1013-1019 CrossRef
  9. Utsunomiya, T, Shimada, M, Hanaoka, J (2012) Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve. J Gastroenterol 47: pp. 470-476 CrossRef
  10. Saito, K, Ledsam, J, Sourbron, S (2014) Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPA dynamic contrast-enhanced MRI: a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention. Eur Radiol 24: pp. 112-119 CrossRef
  11. Saito, S, Moriyama, Y, Kobayashi, S (2012) Assessment of liver function in thioacetamide-induced rat acute liver injury using an empirical mathematical model and dynamic contrast-enhanced MRI with Gd-EOB-DTPA. J Magn Reson Imaging 36: pp. 1483-1489 CrossRef
  12. Kim, SU, Kim, YC, Choi, JS (2010) Can preoperative diffusion-weighted MRI predict postoperative hepatic insufficiency after curative resection of HBV-related hepatocellular carcinoma? A pilot study. Magn Reson Imaging 28: pp. 802-811 CrossRef
  13. Materne, R, Smith, AM, Peeters, F (2002) Assessment of hepatic perfusion parameters with dynamic MRI. Magn Reson Med 47: pp. 135-142 CrossRef
  14. Ding, Y, Rao, SX, Meng, T, Chen, C, Li, R, Zeng, MS (2014) Usefulness of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging in assessment of non-alcoholic fatty liver disease. Eur Radiol 24: pp. 959-966 CrossRef
  15. Katsube, T, Okada, M, Kumano, S (2011) Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Investig Radiol 46: pp. 277-283 CrossRef
  16. Haimerl, M,
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objectives To compare the potential of T1 mapping on gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) for assessing liver function in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods One hundred consecutive patients with known HBV-related HCCs were included. T1 relaxation time and apparent diffusion coefficient (ADC) of the liver were measured, and the reduction rate of T1 relaxation time (?) was calculated. T1 relaxation time measurements were compared with ADC values according to the Model for End-Stage Liver Disease (MELD) score. Results Hepatobiliary phase (HBP) and ? of T1 relaxation time measurements showed significant correlations with MELD score (rho--.571, p--.0001; rho-??0.573, p--.0001, respectively). HBP and ? of T1 relaxation time were significantly different between good (MELD ?) and poor liver function (MELD ?) (p--.0001 for both). Areas under the receiver operating characteristic curves (AUCs) of T1 relaxation time for HBP (AUC 0.84) and ? (AUC 0.82) were significantly better than for ADC (AUC 0.53; p--.0001). Conclusions T1 mapping on Gd-EOB-DTPA-enhanced MRI showed promise for evaluating liver function in patients with HBV-related HCC, while DWI was not reliable. HBP T1 relaxation time measurement was equally accurate as ? measurement. Key Points -T 1 mapping on Gd-EOB-DTPA MRI was accurate for assessing liver function. -HBP T 1 relaxation time measurement was as accurate as ??T 1 -T 1 mapping on Gd-EOB-DTPA MRI was more accurate than DWI-ADC measurement.