Astrocyte elevated gene-1: a novel independent prognostic biomarker for metastatic ovarian tumors

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• 作者：Cong Li (1)
  Kexin Chen (1)
  Jianping Cai (1)
  Qing-Tao Shi (1)
  Yinghong Li (3)
  Lejing Li (3)
  Hongtao Song (1)
  Huilei Qiu (3)
  Yu Qin (1)
  Jing-Shu Geng (1) (2)
  
• 关键词：Astrocyte elevated gene ; 1 ; Metastasis ; Ovarian cancer ; Biomarker
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：35
• 期：4
• 页码：3079-3085
• 全文大小：157 KB
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• 作者单位：Cong Li (1)
  Kexin Chen (1)
  Jianping Cai (1)
  Qing-Tao Shi (1)
  Yinghong Li (3)
  Lejing Li (3)
  Hongtao Song (1)
  Huilei Qiu (3)
  Yu Qin (1)
  Jing-Shu Geng (1) (2)
  
  1. Department of Pathology, The Third Affiliated (Tumour) Hospital, Harbin Medical University, Harbin, 150040, China
  3. Department of Medicine, The Third Affiliated (Tumour) Hospital, Harbin Medical University, Harbin, 150040, China
  2. Department of Medical Genetics, Harbin Medical University, Harbin, 150086, China
  
• ISSN：1423-0380

文摘

Astrocyte elevated gene-1 (AEG-1), a novel tumor-associated gene, was found overexpressed in many tumors. Therefore, our purpose is to estimate whether AEG-1 overexpression is a novel predictor of prognostic marker in metastatic ovarian tumors. Immunohistochemistry was used to estimate AEG-1 overexpression in metastatic ovarian tumors from 102 samples. The association between AEG-1 expression and prognosis was estimated by univariate and multivariate survival analyses with Cox regression. The log-rank test was used to identify any differences in the prognosis between the two groups. The median overall and progression-free survival rates of patients with tumors from gastrointestinal tract origin were 0.97 and 0.51?years, respectively. Similarly, survival rates of patients with tumors of breast origin were 2.68 and 1.96?years (P-lt;-.0001). Of 102 patients, 77 had high expression, and AEG-1 overexpression had a significant link of prognosis in metastatic ovarian patients (P-lt;-.01). On the other hand, medians of overall survival and progression-free survival of patients with tumors of gastrointestinal tract origin were significantly lower than those of patients with tumors of breast origin (P-lt;-.0001). Patients with metastatic ovarian tumors of breast origin had significantly better prognosis than those with the tumors from gastrointestinal tract primary malignancies. It is suggested that AEG-1 overexpression might be an independent prognostic marker of metastatic ovarian tumors.