Phytochemistry and biosynthesis of δ-lactone withanolides
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- 作者：Bing-You Yang ; Yong-Gang Xia ; Juan Pan ; Yan Liu ; Qiu-Hong Wang…
- 关键词：Biosynthesis ; Classification ; Phytochemistry ; Spectra
- 刊名：Phytochemistry Reviews
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：15
- 期：5
- 页码：771-797
- 全文大小：1,487 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Plant Sciences
Biochemistry
Organic Chemistry
Chemistry - 出版者：Springer Netherlands
- ISSN：1572-980X
- 卷排序：15
文摘
Withanolides are highly oxygenated natural products. These C28 steroids with ergostane-based skeletons functionalized at C-22 and C-26 form six-membered δ-lactone rings. Withanolides containing a δ-lactone side chain often occur in Solanaceae and have a variety of biological activities because of their complicated structures. Characteristic spectroscopic behaviors and biosynthesis of withanolides are conducive to their structural elucidation and “biomimetic synthesis”, respectively. However, the last review to summarize their spectroscopic features and biosynthesis was in 1996. Since then, many withanolides with novel structures have been described by their spectra with biosynthesis investigated with many bioassays. This review surveys δ-lactone withanolides and emphasizes their spectral features, configurations and biosynthetic genes. The period reviewed includes through January 2014. We also include phytochemical species.