MicroRNA roles in beta-catenin pathway
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- 作者：Kai Huang (1) (2) (3)
Jun-Xia Zhang (1) (2) (4)
Lei Han (1) (2) (3)
Yong-Ping You (4)
Tao Jiang (5)
Pei-Yu Pu (1) (2) (3)
Chun-Sheng Kang (1) (2) (3) - 刊名：Molecular Cancer
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：9
- 期：1
- 全文大小：2468KB
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Jun-Xia Zhang (1) (2) (4)
Lei Han (1) (2) (3)
Yong-Ping You (4)
Tao Jiang (5)
Pei-Yu Pu (1) (2) (3)
Chun-Sheng Kang (1) (2) (3)
1. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, China
2. Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, 300052, China
3. Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin, 300052, China
4. Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
5. Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, 100050, China - ISSN：1476-4598
文摘
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.