Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

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• 作者：Weining Wang ; N. Gopalakrishna Iyer ; Hsien Ts'ung Tay ; Yonghui Wu…
• 关键词：Hepatocellular carcinoma ; Ectopic ; Orthotopic ; Xenograft ; HepG2 cell line
• 刊名：BMC Cancer
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：1,803 KB
• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

Background Despite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy. Unfortunately, drugs that are successful in preclinical studies often fail in the clinical setting, and we hypothesize that this is due to functional differences between primary tumors and commonly used preclinical models. In this study, we attempt to answer this question by comparing tumor morphology and gene expression profiles between primary tumors, xenografts and HCC cell lines.