Cytokine Profile of a Self-Healing Fonsecaea pedrosoi Infection in Murine Model
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- 作者：Hong Wang (1)
Weidong Mu (2)
Qing Ja (3)
Miao Zhang (4)
Ruie Chen (5)
Guixia Lv (6)
Yongnian Shen (6)
Weida Liu (6) - 关键词：Cytokine ; Fonsecaea pedrosoi ; Chromoblastomycosis
- 刊名：Cell Biochemistry and Biophysics
- 出版年：2013
- 出版时间：November 2013
- 年：2013
- 卷：67
- 期：2
- 页码：599-605
- 全文大小：
- 作者单位：Hong Wang (1)
Weidong Mu (2)
Qing Ja (3)
Miao Zhang (4)
Ruie Chen (5)
Guixia Lv (6)
Yongnian Shen (6)
Weida Liu (6)
1. Department of Dermatology, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People Republic of China
2. Department of Traumatic Orthopaedics, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People Republic of China
3. Institute of Basic Medicine, Shan Dong Academy of Medicial Sciences, 18877 Jing Shi Road, Jinan, 250021, People Republic of China
4. Department of Clinical Laboratory, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People Republic of China
5. Department of Laboratory, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, People Republic of China
6. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiang Wang Miao Street, Nanjing, 210042, People Republic of China - ISSN：1559-0283
文摘
Chromoblastomycosis is a chronic infectious disease of the skin and subcutaneous tissue. However, the host-defence response to this fungal infection has not been investigated thoroughly. This study was carried out to analyse the sequential events and the change of local cytokine release in a murine model infected with Fonsecaea pedrosoi in footpad. The anti-inflammatory Th2 cytokine IL-10 demonstrated an upward trend up to 7days post infection followed by a steady decline. The titers of TNF-(a pro-inflammatory Th1 cytokine) increased up to 7days post infection followed by a relatively steady-state until full recovery. The anti-inflammatory cytokine IL-4 showed a similar pattern as TNF- The pro-inflammatory cytokine IFN-did not increased until 7days post infection, while demonstrated an upward trend up to 30days when the mice reached a full recovery from infection.