An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer’s Disease

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• 作者：Ning Shen ; Bin Chen ; Yongshuai Jiang ; Rennan Feng ; Mingzhi Liao…
• 关键词：Alzheimer’s disease ; Complement receptor 1 ; Polymorphism
• 刊名：Molecular Neurobiology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：51
• 期：3
• 页码：1017-1023
• 全文大小：532 KB
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• 作者单位：Ning Shen (1)
  Bin Chen (2)
  Yongshuai Jiang (3)
  Rennan Feng (4)
  Mingzhi Liao (3)
  Liangcai Zhang (5)
  Fujun Li (6)
  Guoda Ma (7)
  Zugen Chen (8)
  Bin Zhao (9)
  Keshen Li (8) (9)
  Guiyou Liu (10)
  
  1. Department of Physiology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, China
  2. Department of Endocrinology and Metabolism, The Military General Hospital of Beijing PLA, Beijing, China
  3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
  4. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China
  5. Department of Statistics, Rice University, Houston, TX, USA
  6. Department of Anesthesiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China
  7. Institute of Neurology, Guangdong Medical College, 524001, Zhanjiang, China
  8. Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA
  9. Key laboratory of Aging-Related Cardio-Cerebral Diseases of Guangdong Province, Affiliated Hospital of Guangdong Medical College, 524001, Zhanjiang, China
  10. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, 300308, Tianjin, China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

The complement receptor 1 (CR1) rs6656401 polymorphism was first identified to be associated with Alzheimer’s disease (AD) in European ancestry. However, the following studies reported weak or no significant association in Chinese, Japanese, Korean, African-American, Polish, and Canadian populations. We think that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous genome-wide association studies (GWAS) in European ancestry or the genetic heterogeneity of the rs6656401 polymorphism in different populations. Here, we reevaluated this association using the relatively large-scale samples from previous 24 studies (N--5,939, 30,100 cases and 55,839 controls) by searching the PubMed, AlzGene, and Google Scholar databases. Using additive model, we did not identify significant heterogeneity among the 24 studies. We observed significant association between the rs6656401 polymorphism and AD in pooled populations (P--.82E-26, odds ratio (OR)--.18, 95?% confidence interval (CI) 1.15-.22). In subgroup analysis, we identified significant results in East Asian population with P--.00E-04, OR--.31, 95?% CI 1.13-.52. To our knowledge, this is the first meta-analysis to investigate the association between rs6656401 polymorphism and AD in East Asian, African-American, Canadian, and European populations. Our analysis further supports previous findings that the CR1 rs6656401 polymorphism contributes to AD susceptibility. We believe that our findings will be very useful for future genetic studies on AD.