CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations

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• 作者：Shuyan Zhang ; Xuling Li ; Guoda Ma ; Yongshuai Jiang ; Mingzhi Liao…
• 关键词：Alzheimer’s disease ; Single nucleotide polymorphisms ; Genome ; wide association studies (GWAS)
• 刊名：Molecular Neurobiology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：53
• 期：3
• 页码：1446-1451
• 全文大小：372 KB
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• 作者单位：Shuyan Zhang (1)
  Xuling Li (1)
  Guoda Ma (2)
  Yongshuai Jiang (3)
  Mingzhi Liao (4)
  Rennan Feng (5)
  Liangcai Zhang (6)
  Jiafeng Liu (7)
  Guangyu Wang (8)
  Bin Zhao (2)
  Qinghua Jiang (9)
  Keshen Li (2)
  Guiyou Liu (10)
  
  1. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China
  2. Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China
  3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
  4. College of Life Science, Northwest A&F University, Yangling, Shaanxi, China
  5. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China
  6. Department of Statistics, Rice University, Houston, TX, USA
  7. Department of Neurology, The First Hospital of Harbin, Harbin, China
  8. Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China
  9. School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China
  10. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer’s disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between rs9331888 polymorphism and AD in Asian population. Here, we searched the PubMed, AlzGene, and Google Scholar databases. We selected 12 independent studies that evaluated the association between the rs9331888 polymorphism and AD using a case-control design. Using an additive model, we did not identify significant heterogeneity among these 12 studies. We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E − 07, odds ratio (OR) = 1.10, 95 % confidence interval (CI) 1.06–1.14). In subgroup analysis, we did not identify significant heterogeneity in both Asian and Caucasian populations. We identified significant association in Caucasian population (P = 1.67E − 08, OR = 1.13, 95 % CI 1.08–1.18) but not in East Asian population (P = 0.49, OR = 1.02, 95 % CI 0.96–1.10).