The role of MC1R gene in buffalo coat color

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• 作者：YongWang Miao (1) (2)
  GuiSheng Wu (3)
  Lei Wang (2)
  DaLin Li (4)
  ShouKun Tang (5)
  JianPing Liang (2)
  HuaMing Mao (2)
  HuaiRong Luo (3)
  YaPing Zhang (1) (6)
  
• 关键词：Buffalo ; coat color ; MC1R
• 刊名：Science China Life Sciences
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：53
• 期：2
• 页码：267-272
• 全文大小：1386KB
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• 作者单位：YongWang Miao (1) (2)
  GuiSheng Wu (3)
  Lei Wang (2)
  DaLin Li (4)
  ShouKun Tang (5)
  JianPing Liang (2)
  HuaMing Mao (2)
  HuaiRong Luo (3)
  YaPing Zhang (1) (6)
  
  1. Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, 650091, China
  2. Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, 650201, China
  3. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China
  4. Yunnan Institute of Buffalo Science and Technology, Kunming, 650021, China
  5. Animal Husbandry and Veterinary Station of Luxi city, Luxi, 678400, China
  6. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
  

文摘

Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many species. To investigate if the MC1R gene is associated with coat color in water buffalo, the coding region of MC1R gene of 216 buffalo samples was sequenced, which included 49 black river buffalo (Murrah and Nili-Ravi), 136 swamp buffalo (Dehong, Diandongnan, Dechang, Guizhou, and Xilin) with white and gray body, and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp buffalo. Among the three variation sites found, SNP684 was synonymous, while SNP310 and SNP384 were nonsynonymous, leading to p.S104G and p.I128M changes, respectively. Only Individuals carrying homozygote EBR/EBR were black. The genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of MC1R. The in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of MC1R. Above results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.