Cell-penetrating peptide-modified PLGA nanoparticles for enhanced nose-to-brain macromolecular delivery

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• 作者：Lu Yan (11029) (21029)
  Huiyuan Wang (11029)
  Yifan Jiang (11029)
  Jinhua Liu (11029)
  Zhao Wang (11029)
  Yongxin Yang (11029)
  Shengwu Huang (21029)
  Yongzhuo Huang (11029) (31029)
  
• 关键词：cell ; penetrating peptide ; intranasal delivery ; brain target ; insulin ; PLGA nanoparticles
• 刊名：Macromolecular Research
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：21
• 期：4
• 页码：435-441
• 全文大小：991 KB
• 参考文献：1. L. T. Loftus, H. F. Li, A. J. Gray, C. Hirata-Fukae, B. A. Stoica, J. Futami, H. Yamada, P. S. Aisen, and Y. Matsuoka, / Neuroscience, 139, 1061 (2006). CrossRef
  2. J. D. Suman, / Expert Opin. Biol. Ther., 3, 519 (2003). CrossRef
  3. Y. Huang, Y. S. Park, J. Wang, C. Moon, Y. M. Kwon, H. S. Chung, Y. J. Park, and V. C. Yang, / Curr. Pharm. Des., 16, 2369 (2010). CrossRef
  4. U. Langel, / Cell-Penetrating Peptides, Springer, New York, 2010.
  5. J. H. Liu, Y. X. Zhao, Q. Q. Guo, Z. Wang, H. Y. Wang, Y. X. Yang, and Y. Z. Huang, / Biomaterials, 33, 6155 (2012). CrossRef
  6. Y.-H. Wang, C.-P. Chen, M.-H. Chan, M. Chang, Y.-W. Hou, H.-H. Chen, H.-R. Hsu, K. Liu, and H.-J. Lee, / Biochem. Biophys. Res. Commun., 346, 758 (2006). CrossRef
  7. Y.-W. Hou, M.-H. Chan, H.-R. Hsu, B. R. Liu, C.-P. Chen, H.-H. Chen, and H.-J. Lee, / Experimental Dermatology, 16, 999 (2007). CrossRef
  8. E. Cohen and A. Dillin, / Nat. Rev. Neurosci., 9, 759 (2008). CrossRef
  9. Z. Laron, / Arch. Physiol. Biochem., 115, 112 (2009). CrossRef
  10. S. Craft, L. D. Baker, T. J. Montine, S. Minoshima, G. S. Watson, A. Claxton, M. Arbuckle, M. Callaghan, E. Tsai, S. R. Plymate, P. S. Green, J. Leverenz, D. Cross, and B. Gerton, / Arch. Neurol., 69, 29 (2012). CrossRef
  11. C. E. Astete and C. M. Sabliov, / J. Biomater. Sci. Polym. Ed., 17, 247 (2006). CrossRef
  12. R. Yang, W. S. Shim, F. D. Cui, G. Cheng, X. Han, Q. R. Jin, D. D. Kim, S. J. Chung, and C. K. Shim, / Int. J. Pharm., 371, 142 (2009). CrossRef
  13. G. F. Liang, Y. L. Zhu, B. Sun, F. H. Hu, T. Tian, S. C. Li, and Z. D. Xiao, / Nanoscale Res. Lett., 6, 447 (2011). CrossRef
  14. S. H. Kim, J. H. Jeong, K. W. Chun, and T. G. Park, / Langmuir, 21, 8852 (2005). CrossRef
  15. V. P. Torchilin, / Adv. Drug Deliv. Rev., 60, 548 (2008). CrossRef
  16. G. Ruan, A. Agrawal, A. I. Marcus, and S. Nie, / J. Am. Chem. Soc., 129, 14759 (2007). CrossRef
  17. A. Som, A. O. Tezgel, G. J. Gabriel, and G. N. Tew, / Angew. Chem. Int. Ed. Engl., 50, 6147 (2011). CrossRef
  18. Q. Cai, G. Shi, J. Bei, and S. Wang, / Biomaterials, 24, 629 (2003). CrossRef
  19. H. Pan, H. Jiang, and W. Chen, / Biomaterials, 29, 1583 (2008). CrossRef
  20. S. R. Schwarze, A. Ho, A. Vocero-Akbani, and S. F. Dowdy, / Science, 285, 1569 (1999). CrossRef
  21. G. P. Dietz and M. Bahr, / Brain Res. Bull., 68, 103 (2005). CrossRef
  22. H. He, A. David, J. Zhang, Y. Park, J. Wang, Y. Huang, J. Wang, and V. Yang, / Macromol. Res., 19, 1224 (2011). CrossRef
  23. J. F. Liang and V. C. Yang, / Biochem. Biophys. Res. Commun., 335, 734 (2005). CrossRef
  24. R. C. Mundargi, V. R. Babu, V. Rangaswamy, P. Patel, and T. M. Aminabhavi, / J. Control. Release, 125, 193 (2008). CrossRef
  25. Z. Wen, Z. Yan, R. He, Z. Pang, L. Guo, Y. Qian, X. Jiang, and L. Fang, / Drug Deliv., 18, 555 (2011).
  26. B. Semete, L. Booysen, Y. Lemmer, L. Kalombo, L. Katata, J. Verschoor, and H. S. Swai, / Nanomedicine, 6, 662 (2010). CrossRef
  
• 作者单位：Lu Yan (11029) (21029)
  Huiyuan Wang (11029)
  Yifan Jiang (11029)
  Jinhua Liu (11029)
  Zhao Wang (11029)
  Yongxin Yang (11029)
  Shengwu Huang (21029)
  Yongzhuo Huang (11029) (31029)
  
  11029. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Hai-ke Rd, Shanghai, 201203, P. R. China
  21029. College of Pharmaceutical Sciences, Zhejiang University of TCM, 548 Bing-wen Rd, Hangzhou, 310053, P. R. China
  31029. Ministry of Education & PLA, Key Lab of Smart Drug Delivery (Fudan University), Shanghai, P. R. China
  
• ISSN：2092-7673

文摘

Macromolecular drugs become an essential part in neuroprotective treatment. However, the nature of ineffective delivery crossing the blood brain barrier (BBB) renders those macromolecules undruggable for clinical practice. Recently, brain target via intranasal delivery have provided a promising solution to circumventing the BBB. Despite the direct route from nose to brain (i.e. olfactory pathway), there still are big challenges for large compounds like proteins to overcome the multiple delivery barriers such as nasal mucosa penetration, intracellular transport along the olfactory neuron, and diffusion across the heterogeneous brain compartments. Herein presented is an intranasal strategy mediated by cell-penetrating peptide modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the delivery of insulin to the brain, a potent therapeutic against Alzheimer’s disease. The results revealed that the cell-penetrating peptide can potentially deliver insulin into brain via the nasal route, showing a total brain delivery efficiency of 6%. It could serve as a potential treatment for neurodegenerative diseases.